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View Structure Prediction Details

Protein: Axn-PC, FBpp0306758
Organism: Drosophila melanogaster
Length: 739 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Axn-PC, FBpp0306758.

Description E-value Query
Range
Subject
Range
Axn-PA, Axn-PB - The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597). It is a protei...
483.0 [0..1] [739..1]

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Predicted Domain #1
Region A:
Residues: [1-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGHPSGIRK HDDNECSGPR PPVPGEESRV KKMTEGVADT SKNSSPSYLN WARTLNHLLE  60
   61 DRDGVELFKK YVEEEAPAYN DHLNFYFACE GLKQQTDPEK IKQIIGAIYR FLRKSQLSIS 120
  121 DDLRAQIKAI KTNPEIPLSP HIFDPMQRHV EVTIRDNIYP TFLCSEMYIL YIQQMSAQQE 180
  181 RCTSSGATGS GSAGSSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.69897
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
beta-catenin binding 1.80347214616493 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
armadillo repeat domain binding 0.461171601616737 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [198-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGGSSLAGAC ALPPTTASGK QQLPQLVPPG AFINLPVSSV SGPPAGTCSA SGSVYGPSTS  60
   61 ASSSGSISAT DTLPRSSTLP TLHEDSVLSL CDDFEKVQMQ EGGGSLGSGS VGAGARAPDY 120
  121 PIRLTRDLLI ATQKRRLEIR PPGAHGYVYN PSTTNTSYVP NSRVDSERAS VSSGGRTDSD 180
  181 TMSISSCSMD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [388-655]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRPYIQRRHS STESKAIRQS AMANKETNTF QVIPRTQRLH SNEHRPLKEE ELVSLLIPKL  60
   61 EEVKRKRDLE ERARERNPGA ALLTNERSSA SDRAFAEAIR EKFALDEDND QDILDQHVSR 120
  121 VWKDQTPHRS PGTMSPCPPI PSRRRTATHD SGMVSDGAMS LSGHSMKHSK SMPDHSSCSR 180
  181 KLTNKWPSMN TDSGISMFSA DTVTKYKDAS TASKLEEAKR RLEDEPRRSR RYAQPPMQHL 240
  241 SQQPLASFSS SSSGGSISLP HQPPPLPA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [656-739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPPETIVVFS FCEEPVPYRI KIPGTQPTLR QFKDYLPRRG HFRFFFKTHC EDPDSPVIQE  60
   61 EIVNDSDILP LFGDKAMGLV KPSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.522879
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle