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View Structure Prediction Details

Protein: loco-PC
Organism: Drosophila melanogaster
Length: 829 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for loco-PC.

Description E-value Query
Range		 Subject
Range
loco-PD - The gene locomotion defects is referred to in FlyBase by the symbol Dmel\loco (CG5248, FBgn0020278)....
 554.0 [0..2] [829..714]

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Predicted Domain #1
Region A:
Residues: [1-252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRALPANAS PFRRAWGQSS FRTPRSDKVA KEQQQLGQSS PVRRTASMNA SDNDMYIKTL  60
   61 MLDSDLKSSR SQHQLSLLQV PKVLTTPAPP SAITASVAAE GAAQDHGCPS SWAGSFERML 120
  121 QDAAGMQTFS EFLKKEFSAE NIYFWTACER YRLLESEADR VAQAREIFAK HLANNSSDPV 180
  181 NVDSQARSLT EEKLADAAPD IFAPAQKQIF SLMKFDSYQR FIRSDLYKSC VEAEQKNQPL 240
  241 PYSGLDLDEL LK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.522879
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
signal transducer activity 1.14361809679544 bayes_pls_golite062009
molecular transducer activity 1.14361809679544 bayes_pls_golite062009
beta-catenin binding 0.59248827140739 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [253-325] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNFHLGAFSK LKKSASNAED RRRKSLLPWH RKTRSKSRDR TEIMADMQHA LMPAPPVPQN  60
   61 APLTSASLKL VCG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [326-436] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNSLSDLHSS RSSLSSFDAG TATGGQGAST ESVYSLCRVI LTDGATTIVQ TRPGETVGEL  60
   61 VERLLEKRNL VYPYYDIVFQ GSTKSIDVQQ PSQILAGKEV VIERRVAFKL D

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.31
Match: 1rrbA
Description: THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.28306198153429 bayes_pls_golite062009
binding 2.0688320293797 bayes_pls_golite062009
protein binding 1.72968950672856 bayes_pls_golite062009
signal transducer activity 1.07208466109379 bayes_pls_golite062009
molecular transducer activity 1.07208466109379 bayes_pls_golite062009
receptor binding 0.286966350616338 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [437-548] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPDPKVISVK SKPKKQLHEV IRPILSKYNY KMEQVQVIMR DTQVPIDLNQ PVTMADGQRL  60
   61 RIVMVNSDFQ VGGGSSMPPK QSKPMKPLPQ GHLDELTNKV FNELLASKAD AA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.522879
Match: 1wfyA
Description: Solution structure of the Ras-binding domain of mouse RGS14
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.3713276381973 bayes_pls_golite062009
binding 2.14676646738549 bayes_pls_golite062009
protein binding 1.86841453215444 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
receptor binding 0.298046142314417 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [549-708] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASEKSRPVDL CSMKSNEAPS ETSSLFERMR RQQRDGGNIP ASKLPKLKKK STSSSQQSEE  60
   61 AATTQAVADP KKPIIAKLKA GVKLQVTERV AEHQDELLEG LKRAQLARLE DQRGTEINFD 120
  121 LPDFLKNKEN LSAAVSKLRK VRASLSPVSK VPATPTEIPQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [709-829] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAPRLSITRS QQPVSPMKVD QEPETDLPAA TQDQTEFAKA PPPLPPKPKV LPIKPSNWGV  60
   61 AQPTGNYCNK YSPSKQVPTS PKEASKPGTF ASKIPLDLGR KSLEEAGSRC AYLDEPSSSF 120
  121 V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle