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View Structure Prediction Details

Protein: Brf-PA, Brf-PB
Organism: Drosophila melanogaster
Length: 662 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Brf-PA, Brf-PB.

Description E-value Query
Range
Subject
Range
gi|109480055, gi... - gi|62651305|ref|XP_216801.3| PREDICTED: similar to transcription initiation factor IIIB [Rattus norv...
458.0 [0..3] [662..2]

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Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTGLKCRNC GSNEIEEDNA RGDRVCMNCG SVLEDSLIVS EVQFEEVGHG AAAIGQFVSA  60
   61 ESSGGATNYG 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.67
Match: 1rlyA
Description: RDC-derived models of the zinc ribbon domain of human general transcription TFIIB (zinc bound structures)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.22680674586367 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [71-283]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGKFQVGSGT ESREVTIKKA KKDITLLCQQ LQLSQHYADT ALNFFKMALG RHLTRGRKST  60
   61 HIYAACVYMT CRTEGTSHLL IDISDVQQIC SYELGRTYLK LSHALCINIP SLDPCLYIMR 120
  121 FANRLQLGAK THEVSMTALR IVQRMKKDCM HSGRRPTGLC GAALLIAARM HDFSRTMLDV 180
  181 IGVVKIHEST LRKRLSEFAE TPSGGLTLEE FMT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.045757
Match: 1c9bA
Description: Transcription factor IIB (TFIIB), core domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [284-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDLEREQDPP SFKAARKKDR ERIKDMGEHE LTELQKEIDA HLEKDLGKYS NSVYRQLTKG  60
   61 KGLSPLSSPS TPNSSSEKDI ELEESRQFIE QSNAEVIKEL IAKNEDVKKS EPGGLVAGIE 120
  121 GLRPDIEAIC RVTQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [418-488]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDLEDVEKAK QPQEQELITD DLNDDELDQY VLTEEESVAK LEMWKNLNAE YLQEQKERDE  60
   61 RLAKEREEGK P

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.39
Match: 1ngmB
Description: TBP-binding domain of the transcription factor IIIb Brf1 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [489-662]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERKKRKPRKK VIGPSSTAGE AIEKMLQEKK ISSKINYEIL KTLTDGMGGL TDDSPTTSAD  60
   61 TKPSTLEELK HQPVIVEEGP VASKSRGNRA AYDLPGPSRK RPKLEVGLPV SKAADVEQAE 120
  121 TKPAVVVEAD DLDEDADDPD VEPEAEPEAT LQDMLNTGGD DDEFGYGFDE EEEY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle