YRC Public Data Repository - Protein Structure Prediction

Protein:	Manf-PA
Organism:	Drosophila melanogaster
Length:	173 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Manf-PA.

Description	E-value	Query Range	Subject Range
gi\|114587110 - gi\|114587110\|ref\|XP_001169644.1\| PREDICTED: similar to arginine-rich protein [Pan troglodytes]	279.0	[0..8]	[169..74]
gi\|284164, gi\|178991 - gi\|284164\|pir\|\|S27956 arginine-rich protein - human, gi\|178991\|gb\|AAB08753.1\| arginine-rich protein ...	278.0	[0..8]	[169..62]
gi\|30585119 - gi\|30585119\|gb\|AAP36832.1\| Homo sapiens arginine-rich, mutated in early stage tumors [synthetic cons...	267.0	[0..8]	[169..10]
MANF_BOVIN - Mesencephalic astrocyte-derived neurotrophic factor OS=Bos taurus GN=MANF PE=1 SV=2	265.0	[0..8]	[169..7]
gi\|110625813, gi... - gi\|74227026\|dbj\|BAE38314.1\| unnamed protein product [Mus musculus], gi\|74204855\|dbj\|BAE20927.1\| unna... MANF_RAT - Mesencephalic astrocyte-derived neurotrophic factor OS=Rattus norvegicus GN=Manf PE=1 SV=1	264.0	[0..8]	[169..7]
MANF_MOUSE - Mesencephalic astrocyte-derived neurotrophic factor OS=Mus musculus GN=Manf PE=1 SV=1	264.0	[0..8]	[169..7]
gi\|4894786 - gi\|4894786\|gb\|AAD32615.1\|AF132912_1 ARP-like protein [Drosophila melanogaster]	262.0	[0..1]	[173..1]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTWYMVVVI GFLATLAQTS LALKEEDCEV CVKTVRRFAD SLDDSTKKDY KQIETAFKKF  60
   61 CKAQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE KICEKLKKKD AQICDLRYEK 120
  121 QIDLNSVDLK KLKVRDLKKI LNDWDESCDG CLEKGDFIKR IEELKPKYSR SEL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.18
Match:	1y02A
Description:	Crystal Structure of a FYVE-type domain from caspase regulator CARP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.561606449522564	bayes_pls_golite062009
receptor binding	0.177430744933542	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: