YRC Public Data Repository - Protein Structure Prediction

Protein:	CG6188-PA
Organism:	Drosophila melanogaster
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG6188-PA.

Description	E-value	Query Range	Subject Range
gi\|54637804, gi\|... - gi\|54637804\|gb\|EAL27206.1\| GA19423 [Drosophila pseudoobscura pseudoobscura], gi\|125773621\|ref\|XP_001... gi\|54637804\|gb\|E... - GA19423-PA [Drosophila pseudoobscura], GA19423 [Drosophila pseudoobscura pseudoobscura] gi\|194106095, gi... - gi\|195166224\|ref\|XP_002023935.1\| GL27149 [Drosophila persimilis], gi\|194106095\|gb\|EDW28138.1\| GL2714...	192.0	[0..1]	[289..1]
gi\|61872960 - gi\|61872960\|ref\|XP_618409.1\| PREDICTED: similar to glycine N-methyltransferase isoform 1 [Bos taurus...	183.0	[0..6]	[286..3]
gi\|57094478 - gi\|57094478\|ref\|XP_532140.1\| PREDICTED: similar to Glycine N-methyltransferase isoform 1 [Canis fami...	180.0	[0..6]	[286..3]
gi\|8671582 - gi\|8671582\|gb\|AAF78289.1\| glycine N-methyltransferase [Homo sapiens]	178.0	[0..6]	[286..3]
GNMT_RABIT - Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1	178.0	[0..6]	[286..1]
gi\|109071194 - gi\|109071194\|ref\|XP_001089876.1\| PREDICTED: glycine N-methyltransferase [Macaca mulatta]	177.0	[0..6]	[286..3]
gi\|38383074, gi\|... - gi\|47086405\|ref\|NP_997981.1\| glycine N-methyltransferase [Danio rerio], gi\|38383074\|gb\|AAH62527.1\| G...	173.0	[0..6]	[286..3]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSADSVFV ARSDGISAEG VRDQYADGKA AKVWEIFIGD KNSRTDNYKN FLIDMLRNKG  60
   61 CKRVLDVACG TGVDSLMLVE EGFEVVSVDA SDKMLKYALK ERWARRNEAA FDKWVIEEAN 120
  121 WLTLYDDIQE HIQDGFDAVI CLGNSFAHLM DGFGDQREHK QAIGNFEKCL KPGGVLLIDH 180
  181 RNYDNILETG ATPAKSIYYN TSHTADIKTS VLFYCGKPAL VSMDYLIAGN KLTSEFRLSY 240
  241 YPHGLKRFQE ILAEIFSAKA KHQLYGDFKE MSQVKNPAFY IHLIEKPQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.522879
Match:	1r74A
Description:	Crystal Structure of Human Glycine N-Methyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity	2.926540904444	bayes_pls_golite062009
methyltransferase activity	1.75500643076741	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	1.71409699782588	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.67663666042395	bayes_pls_golite062009
N-methyltransferase activity	1.57269280784007	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
protein methyltransferase activity	1.09292825105169	bayes_pls_golite062009
RNA methyltransferase activity	0.817509452491588	bayes_pls_golite062009
thiopurine S-methyltransferase activity	0.74333485845978	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009
rRNA methyltransferase activity	0.230719796976667	bayes_pls_golite062009
histone methyltransferase activity	0.21038834597251	bayes_pls_golite062009
nucleic acid binding	0.103639608104023	bayes_pls_golite062009
DNA binding	0.0844856573974502	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: