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View Structure Prediction Details

Protein: mfas-PJ
Organism: Drosophila melanogaster
Length: 905 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mfas-PJ.

Description E-value Query
Range
Subject
Range
gi|3004962 - gi|3004962|gb|AAC09252.1| midline fasciclin precursor [Drosophila melanogaster]
681.0 [0..12] [905..12]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRLWACLLL LGSIQIQAVP FYGDSSSEEV AEFDDSSDST HESSDNSSFM PHLTHPLPAH  60
   61 RNLFAPLPFA PLAPLEP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [78-380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDPLHAQASQ RMASVWNGPA PLAPQLHSSH LLPLFSSGYD TEFVPLEHQQ QPQGRQETAA  60
   61 TVPAQTPSGV EQKPFNVDTI TTDVNSPNPA IFFQQSFPFF GNEFFNSFGG FGFGAAQEPW 120
  121 WKGPNVCTEK EEDETVASET EAEETVDTFG QERDGVTNVV RSPLFGQFQF SVNSCAEKPN 180
  181 KHVCTKIVNQ NGKKKTLTLT RQCCYGYGRP RNADFTTPCE KIDIKDVEAT ASDMGAKQFL 240
  241 ESARTAGELA DMLGAGSGKK VTLFVPNDAA FMEYRGHHQQ ENNVEDAKAE ASKPSIYKLH 300
  301 AVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1igrA
Description: Type 1 insulin-like growth factor receptor extracellular domain; Type 1 insulin-like growth factor receptor Cys-rich domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor binding 4.69491298348348 bayes_pls_golite062009
extracellular matrix structural constituent 4.44612590443184 bayes_pls_golite062009
insulin-like growth factor binding 4.02348040390921 bayes_pls_golite062009
insulin-like growth factor I binding 3.71525343314197 bayes_pls_golite062009
binding 2.20806191972252 bayes_pls_golite062009
protein binding 1.73992312316472 bayes_pls_golite062009
receptor binding 1.71462229979093 bayes_pls_golite062009
glycosaminoglycan binding 1.37184133178431 bayes_pls_golite062009
insulin-like growth factor II binding 0.992669332214511 bayes_pls_golite062009
extracellular matrix binding 0.907118880836251 bayes_pls_golite062009
polysaccharide binding 0.69382733754772 bayes_pls_golite062009
pattern binding 0.499692374055569 bayes_pls_golite062009
carbohydrate binding 0.343717562511172 bayes_pls_golite062009
protein tyrosine phosphatase activator activity 0.28979948676897 bayes_pls_golite062009
G-protein coupled receptor activity 0.131191540468541 bayes_pls_golite062009
glycoprotein binding 0.1030670765537 bayes_pls_golite062009
collagen binding 0.085405748322021 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [381-606]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVQLEDVPN EKLLQTELPD QKIRINSYQL PAALGLEPYR FAANCVPIEK HDKLSEQALV  60
   61 HTLGGVLKPL TKNLMDIIRE RADMSIMRTV LEKTNLSAML EDDKPVTIFV PTDAAFDKLE 120
  121 PHLRRALKEG RGCASNILKN HLLDLTFCSL ATVPGAKTTA YNLLGEPLLL NRTHRAANQT 180
  181 GPTPIYINNL AKIIDADIMG TNGVLHVIDT ILPTESALPM TSLMSQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.85
Match: 1o70A
Description: Fasciclin I
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [607-905]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNLTIFQRLL EASGYDDQFD DLDNVTIFAP TDKALQNTEW ARMLKEQPEL LNHNLDLLEF  60
   61 LNYHVVKPMI KTCDLSEKSL PTVAGSSVRL NLYSTHALFS DVMNRATVNC ARLVHFDDES 120
  121 CGSVLHQVDR ALAPPKNNML KLLEANPNYS KFLELVRKAN LTQLLSNDSR SLTLLVPKND 180
  181 IFEELNESGE GSKPADPMAL VKTHIVEDVV CCAGIIPTNW PFVRSIESIS GQHLRITRDR 240
  241 RPKIENAGVT KCDVVATNGI LHEINDIIVP RPQRQQQQRP QLIPPGAGYQ PQGDFDVFF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.69897
Match: 1o70A
Description: Fasciclin I
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle