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View Structure Prediction Details

Protein: gi|28573155, gi|...
Organism: Drosophila melanogaster
Length: 1167 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|28573155, gi|....

Description E-value Query
Range
Subject
Range
gi|15292241 - gi|15292241|gb|AAK93389.1| LD43161p [Drosophila melanogaster]
484.0 [0..194] [1167..1]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTREEEEEVR SLLSRHQERI MLDLGSTDLL AVLVKNSVLS QSEEDLLLKP YNAVTPTPSA  60
   61 AASATVEPPG SAPSLTKRKL SAVA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [85-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGSTASGGS AGSGGSGSSR CASVNGDANC DSRSLTPSGG GPCSGLNDAE ILRVQCSNLI  60
   61 DIIAKNGFEK FKQFCYAIEC ECPQLIEDLI ND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.30103
Match: 1ujvA
Description: Solution structure of the second PDZ domain of human membrane associated guanylate kinase inverted-2 (MAGI-2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.6196222853442 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
signal transducer activity 1.06018756723145 bayes_pls_golite062009
molecular transducer activity 1.06018756723145 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
cell adhesion molecule binding 0.403457741099606 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
PDZ domain binding 0.0377679976799299 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [177-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLKTDAANLE DSRDGEKMQK EIETIDYIDK EKENDRNRRA VSYGGDATSS PHSATIPRAA  60
   61 PRRVALMKDP PPPPPPKPQL GSKADSVSHL ASKYPQSEYN LIQKIDSNST LTAPAQYQPQ 120
  121 NFYANTGTIS STNGYGSLLC HASSTTSPLA VRKRDKLLHR FSDAATLGRK LKKKKNTNRT 180
  181 CRSMTEAIEM LADPVIEDEF 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [377-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGDRTTWEYH TVAVTRVPGY GFGIAVSGGR DNPHFANGDP SIAVSDVLKG GPAEDRLQVN  60
   61 DRIISVNGVS LENVEYATAV QVLRDSGNTV QLVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.39794
Match: 2h2bA
Description: No description for 2h2bA was found.

Predicted Domain #5
Region A:
Residues: [471-760]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRRVPLNPIN AAGAVQHQHS HSLSSVGLMA NGSGGVAPTP ITSLSQPNSL NSSLVQNASS  60
   61 GQPIKVTLTK GGKKDDYGVV LGCRLFVKEI SSKAREQLNA NGYSLQEGDI ITRIHNTNCG 120
  121 DTMSLKEAKK IIDGCKERLN LVVLRDITNQ TAVSQLNLNN SASHQASGNI YATHQPQVSG 180
  181 CSSSNNNLED PYLPGGASYS SQNLYVQPPT RTSNGPNING NGLNDEKSNL TPRGRSRGPI 240
  241 MDGVSLQQLD RPVTPTRGRS AAIDEPPRPP PPRGSSGGAA QEDFYSSRRQ 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.59
Match: 1z87A
Description: solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [761-859]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYEERQSAEP RFISFQKEGS VGIRLTGGNE AGIFVTAVQP GSPASLQGLM PGDKILKVND  60
   61 MDMNGVTREE AVLFLLSLQD RIDLIVQYCK EEYDEVVTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1um7A
Description: Solution structure of the third PDZ domain of synapse-associated protein 102
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.6196222853442 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
signal transducer activity 1.06018756723145 bayes_pls_golite062009
molecular transducer activity 1.06018756723145 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
cell adhesion molecule binding 0.403457741099606 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
PDZ domain binding 0.0377679976799299 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [860-1167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRGDSFHIKT HFHCDNPSKG EMAFKAGDVF RVIDTLHNGV VGSWQVLKIG RGHQEMQRGV  60
   61 IPNKSRAEEL ATAQFNATKK EMNANESRGN FFRRRRSTHR RSKSLSRENW DDVVFSDSIS 120
  121 KFPAYERVVL RHPGFVRPVV LFGPVSDLAR ERLAKDFPDK FSTPLQDDDK SAATSGKCRI 180
  181 VRLSNIRDVM DRGKHALLDI TPNAVDRLNY AQFYPVVIFL KTDSKHVIKQ LRHGLPKAAH 240
  241 KSSKKLLEQC QKLERVWSHI FSTQIALSDE ESWYRKLRDS IDLQQSGAVW MSESKTKTKY 300
  301 ISSWSFPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.39794
Match: 1kjwA
Description: Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle