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View Structure Prediction Details

Protein: a-PC, a-PA, a-PB
Organism: Drosophila melanogaster
Length: 1329 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for a-PC, a-PA, a-PB.

Description E-value Query
Range
Subject
Range
gi|54637236, gi|... - gi|54637236|gb|EAL26639.1| GA19824-PA [Drosophila pseudoobscura], gi|125811948|ref|XP_001362059.1| G...
570.0 [0..50] [1328..1]

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Predicted Domain #1
Region A:
Residues: [1-239]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFKTRKST DTYSTLAAQQ QQQQQQQQQH QAEGSNISHS SNSSSNKSHT PATCSNRLNK  60
   61 SIVSSTSISS SLPDLHDKSP VMILSCTTLA SNGATATAAV TATATGTAAT SGGSLQQQQQ 120
  121 QHLQHQQQQQ PLRTATPTCL LSGRQTPSAI SVMSLQEATS LHRQQQQPHQ PPTIYVPVPT 180
  181 KLGNNVNTGN SSATLLLSYG STSSIANLQQ QQQQHAAQYQ QYVAQRLHAA SSSCLYEKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [240-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNASGGASSN KSSLSLTPNG HLPDYKLVTA MPVVVLDDEH KSNSLPATEA SRNSNSSSNM  60
   61 NGSSNSNSLD VSNSNSHSGS STSLASTTRN VFTWGKRMSR KLDLLKRSDS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [350-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAAAHKSHSD LRSLFHSPTH HKSGSGGSSG PSSAKASASP TGGHQNSSGS TTSTLKKCKS  60
   61 GPIETIKQRH QQQQQQQQSV QDVGTGQSQS AQSTPTHQFQ AAARPQKALK NFFHRIGSTG 120
  121 MLNHRSHNLL KASEAAQQAT PAATTLYRSS STSQLSSSSY VKCDDPTEGL NLQREQREQR 180
  181 LPRIASLKS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [539-749]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSCDDIAKVS SCLTASTSSG SAAGSLGSPP SSAAAGGGGT ANSGQHDPSR RGAFPYAFLR  60
   61 SRLSVLPEEN HGNVPGHLKQ QIQRQREQHQ QHQRDLLQQE QTSSPLPQRR SPEQAMLNNV 120
  121 SRNDSITSKD WEPLYQRLSS CLSSNESGYD SDGGATGARL GNNLSISGGD TESIASGTLK 180
  181 RNSLISLSSS EGVGMGMGMS LGLGAPSTRN S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [750-895]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SICSAPVSLG GYNYDYETET IRRRFRQVKL ERKCQEDYIG IVLSPKTVMT NSNEQQYRYL  60
   61 IVELEPYGMA QKDGRLRLGD EIVNVNGKHL RGIQSFAEVQ RLLSSFVDNC IDLVIAHDEV 120
  121 TTVTDFYTKI RIDGMSTQRH RLSYVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1ueqA
Description: Solution Structure of The First PDZ domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.3816879009135 bayes_pls_golite062009
binding 2.18285297573892 bayes_pls_golite062009
receptor binding 0.237609767198544 bayes_pls_golite062009
protein domain specific binding 0.16193472434519 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [896-1110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTQSTDSLSS MQSLQLQQER IQGHNTEQEQ EAQGEDQCDA RSMASVSTMP TPMPLMQHRR  60
   61 SSTPRHSLDV GAPEHELLRR RARSSSGQRS LALTPTPLFA SGSSSCSSSP NHRLLDNEND 120
  121 PANDTDSYTP VYANRAASVC VASSLADDEK WQLLARKRCS EGSALSATPN PQQFGQRTHY 180
  181 ARNSINLANS HYRSLRFAHS RLSSSRLSLF MQAPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1111-1208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSLTVGEGVA NTPSSTATTT TDLTNQQQQQ QNQQQTHQSL YIKHSPKSVS LFSPNPYVNA  60
   61 SSSPASASTS AGAGSSLAPP AAALMHHRPS LPVAKLTI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1209-1329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDEEMAEVIR ASMSEGSGRC TPKTITFFKG PGLKSLGFSI VGGRDSPKGN MGIFVKTVFP  60
   61 SGQAADDGTL QAGDEIVEIN GNSVQGMSHA ETIGLFKNVR EGTIVLKILR RKLQKAKSMG 120
  121 C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 2fneA
Description: The crystal structure of the 13th PDZ domain of MPDZ
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle