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View Structure Prediction Details

Protein: stau-PA
Organism: Drosophila melanogaster
Length: 1026 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for stau-PA.

Description E-value Query
Range
Subject
Range
tr|V9HW54|V9HW54... - Epididymis luminal protein 123 OS=Homo sapiens GN=HEL-123 PE=2 SV=1
gi|134950, gi|15... - gi|158506|gb|AAA73062.1| [D.melanogaster mRNA, complete cds.], gene product, sp|P25159|STAU_DROME Ma...
573.0 [0..1] [1026..1]

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Predicted Domain #1
Region A:
Residues: [1-228]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQHNVHAARP APHIRAAHHH SHSHAHMHLH PGMEQHLGPS LQQQQQPPPP PQQPPHRDLH  60
   61 ARLNHHHLHA QQQQQQQTSS NQAGAVAAAG AAYHHGNINS NSGSNISSNS NQMQKIRQQH 120
  121 QHLSSSNGLL GNQPPGPPPQ AFNPLAGNPA ALAYNQLPPH PPHHMAAHLG SYAAPPPHYY 180
  181 MSQAKPAKYN HYGSNANSNS GSNNSNSNYA PKAILQNTYR NQKVVVPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.09691
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [229-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVQEVTPVPE PPVTTNNATT NSTSNSTVIA SEPVTQEDTS QKPETRQEPA SADDHVSTGN  60
   61 IDATGALSNE DTSSSGR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [306-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGKDKTPMCL VNELARYNKI THQYRLTEER GPAHCKTFTV TLMLGDEEYS ADGFKIKKAQ  60
   61 HLAASKAIEE TMYKHPPPKI RRSEEGGPMR THITPTVELN ALAMKLGQRT FYLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.09691
Match: 1x49A
Description: Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.98844454241303 bayes_pls_golite062009
binding 2.86619976447436 bayes_pls_golite062009
structural constituent of ribosome 2.82435487029184 bayes_pls_golite062009
structural molecule activity 2.66201477910663 bayes_pls_golite062009
tubulin binding 2.64441327259575 bayes_pls_golite062009
microtubule binding 2.56910114599273 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
RNA binding 1.95224155318843 bayes_pls_golite062009
DNA binding 1.49492945560218 bayes_pls_golite062009
transcription regulator activity 1.22178500811874 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
cytoskeletal protein binding 0.935558208370217 bayes_pls_golite062009
transcription activator activity 0.880231812214114 bayes_pls_golite062009
transcription factor activity 0.31021399747574 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [420-482]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPTQIPPTDS IVPPEFAGGH LLTAPGPGMP QPPPPPAYAL RQRLGNGFVP IPSQPMHPHF  60
   61 FHG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [483-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGQRPFPPKF PSRFALPPPL GAHVHHGPNG PFPSVPTPPS KITLFVGKQK FVGIGRTLQQ  60
   61 AKHDAAARAL QVLKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1o0wA
Description: RNase III endonuclease catalytic domain; RNase III, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [558-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAISASEEAL EDSMDEGDKK SPISQVHEIG IKRNMTVHFK VLREEGPAHM KNFITACIVG  60
   61 SIVTEGEGNG KKVSKKRAAE KMLVELQKLP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1ekzA
Description: Staufen, domain III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.98844454241303 bayes_pls_golite062009
binding 2.86619976447436 bayes_pls_golite062009
structural constituent of ribosome 2.82435487029184 bayes_pls_golite062009
structural molecule activity 2.66201477910663 bayes_pls_golite062009
tubulin binding 2.64441327259575 bayes_pls_golite062009
microtubule binding 2.56910114599273 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
RNA binding 1.95224155318843 bayes_pls_golite062009
DNA binding 1.49492945560218 bayes_pls_golite062009
transcription regulator activity 1.22178500811874 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
cytoskeletal protein binding 0.935558208370217 bayes_pls_golite062009
transcription activator activity 0.880231812214114 bayes_pls_golite062009
transcription factor activity 0.31021399747574 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [648-804]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLTPTKQTPL KRIKVKTPGK SGAAAREGSV VSGTDGPTQT GKPERRKRLN PPKDKLIDMD  60
   61 DADNPITKLI QLQQTRKEKE PIFELIAKNG NETARRREFV MEVSASGSTA RGTGNSKKLA 120
  121 KRNAAQALFE LLEAVQVTPT NETQSSEECS TSATMSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1whnA
Description: Solution structure of the dsRBD from hypothetical protein BAB26260
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.98844454241303 bayes_pls_golite062009
binding 2.86619976447436 bayes_pls_golite062009
structural constituent of ribosome 2.82435487029184 bayes_pls_golite062009
structural molecule activity 2.66201477910663 bayes_pls_golite062009
tubulin binding 2.64441327259575 bayes_pls_golite062009
microtubule binding 2.56910114599273 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
RNA binding 1.95224155318843 bayes_pls_golite062009
DNA binding 1.49492945560218 bayes_pls_golite062009
transcription regulator activity 1.22178500811874 bayes_pls_golite062009
double-stranded RNA binding 0.967560318725736 bayes_pls_golite062009
cytoskeletal protein binding 0.935558208370217 bayes_pls_golite062009
transcription activator activity 0.880231812214114 bayes_pls_golite062009
transcription factor activity 0.31021399747574 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [805-1026]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTAPAVEATA EGKVPMVATP VGPMPGILIL RQNKKPAKKR DQIVIVKSNV ESKEEEANKE  60
   61 VAVAAEENSN NSANSGDSSN SSSGDSQATE AASESALNTS TGSNTSGVSS NSSNVGANTD 120
  121 GNNHAESKNN TESSSNSTSN TQSAGVHMKE QLLYLSKLLD FEVNFSDYPK GNHNEFLTIV 180
  181 TLSTHPPQIC HGVGKSSEES QNDAASNALK ILSKLGLNNA MK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.24
Match: 1qu6A
Description: dsRNA-dependent protein kinase pkr
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.80632915073735 bayes_pls_golite062009
binding 2.73737762243378 bayes_pls_golite062009
structural constituent of ribosome 2.69938614227852 bayes_pls_golite062009
tubulin binding 2.59197201719144 bayes_pls_golite062009
structural molecule activity 2.56149875079819 bayes_pls_golite062009
microtubule binding 2.50694560502594 bayes_pls_golite062009
protein binding 2.38844215549064 bayes_pls_golite062009
RNA binding 1.63984513781471 bayes_pls_golite062009
DNA binding 1.44777714653394 bayes_pls_golite062009
transcription regulator activity 1.22603137650888 bayes_pls_golite062009
cytoskeletal protein binding 0.927228352447363 bayes_pls_golite062009
transcription activator activity 0.834760842898207 bayes_pls_golite062009
double-stranded RNA binding 0.402046758389082 bayes_pls_golite062009
transcription factor activity 0.312418023287799 bayes_pls_golite062009
catalytic activity 0.00430305721638241 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle