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View Structure Prediction Details

Protein: skf-PB
Organism: Drosophila melanogaster
Length: 556 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for skf-PB.

Description E-value Query
Range
Subject
Range
gi|54637186, gi|... - gi|54637186|gb|EAL26589.1| GA15582-PA [Drosophila pseudoobscura], gi|125811789|ref|XP_001362009.1| G...
412.0 [0..1] [556..1]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEAVMASDI NWDPALSKLI STLKESENLS NDQEIDFLKA LLESKELNAL VNVHTKVAKV  60
   61 GRDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 1vf6A
Description: 2.1 Angstrom crystal structure of the PALS-1-L27N and PATJ L27 heterodimer complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleobase, nucleoside, nucleotide kinase activity 3.18270433521719 bayes_pls_golite062009
binding 2.4093171025758 bayes_pls_golite062009
nucleotide kinase activity 1.9239399157391 bayes_pls_golite062009
PDZ domain binding 1.88298566187849 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.84086757311516 bayes_pls_golite062009
guanylate kinase activity 1.80396483614769 bayes_pls_golite062009
protein binding 1.15557714383339 bayes_pls_golite062009
protein domain specific binding 0.683298345987 bayes_pls_golite062009
catalytic activity 0.304516551414824 bayes_pls_golite062009
structural molecule activity 0.248599616863115 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLAPVLSTSA QVLYEVLEQL SQHCHLNDDC KEAFHLLQDS HLQHLLFAHD AIAQKDFYPH  60
   61 LPEAPVEMDE DEETIKIVQL VKSNEPLTGA QSTEPIVGAT IKTDEESGKI IIARIMHGGA 120
  121 ADRSGLIHVG DEVIEVNNIN VEGKTPGDVL TILQNSEGTI TFKLVPADNK GA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.39794
Match: 1z87A
Description: solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [237-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRESKVRVRA HFDYNPDVDP YIPCKEAGLA FQRGDVLHIV AQDDAYWWQA RKEHERSARA  60
   61 GLIPSRALQE RRILHDRTQK NGTDLDSKQN DDFDREQIAT YEEVAKLYPR PGVFRPIVLI 120
  121 GAPGVGRNEL RRRLIARDPE KFRSPVPYTT RPMRTGEVAG REYIFVAREK MDADIEAGKF 180
  181 VEHGEYKGHL YGTSAESVKS IVNAGCVCVL SPHYQAIKTL RTAQLKPFLI HVKPPELDIL 240
  241 KATRTEARAK STFDEANARS FTDEEFEDMI KSAERIDFLY GHFFDVELVN GELVNAFEQL 300
  301 VQNVQRLENE PVWAPSMWVQ 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.09691
Match: 1jxmA
Description: Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle