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View Structure Prediction Details

Protein: CAP-PA
Organism: Drosophila melanogaster
Length: 2376 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAP-PA.

Description E-value Query
Range
Subject
Range
gi|14669814 - gi|14669814|dbj|BAB62017.1| DCAPL1 [Drosophila melanogaster]
565.0 [0..1] [2376..1]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNNRNRNRN RNRNKRNRNQ NQNQNPSQNQ NENHQQQAEG AEDREEQQDF QTQIAVAQSS  60
   61 SFVDDNGNSG SVSNGPTENS EEVTNTLEKT EKKEEIFEQP ATVIQKEADS DAEMGAKNSK 120
  121 HRKEKSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [128-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQASNGKSEE QVRPPPTIIR RPPGSPRQAK VIVHRIVREE DTANGKAQSP EPPKAVESKE  60
   61 QHMEVEDSKK EKPEAQQEIE TKEERENEPS PKELPESSHL SEDAQQKHVE VEENQQVYDE 120
  121 VDYSKDETTD NNPQQEQHDS KEPEQYVLQL EKAMEFVENA HQQHVAAVQS YQKQRDTEQN 180
  181 AQQQEQNEAQ HLQESTKAHQ QNIAVPQILV DPKKREEGLA QQLHHD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [354-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKEEPILNNA QQQNDDTAPK SPKEVTIKVQ FQTEDPYSQQ PPPQKPTSKV IIHQIHVETT  60
   61 DEEQNAKPTF EEVSSTTGSL AGTLSPPPRY LVESPKNVSS GQFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [458-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFSRNVQIQE MELNSDFSSG EFNSLQSPLV CEVDSESEGS VVLGPERSPS DQQVPSSSRV  60
   61 EQHEQVRQKR AQYRNALESH FMPQLLNPRY LDSILEENEW RNSTASS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [565-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGSDQTGIRT PKLNETFPRS QLDFSRRHKR REEAPSPLKL ETKLLEESTD LESCTRLQSA  60
   61 LSPQSEDAEL VYLSSSASSS VSDLMELELE QAAALAERAL VDLDTDASRL IARPDDEMSS 120
  121 TSTTTADRSE TEAETETETE REGEQSREST PVNANPTLAS SQSSLLSAAT PTPTPTPTPA 180
  181 DREQLAKDTN VSGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [759-831]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STVSFGAASP LAATREEFVR NMDKVRELIE MTRREQEQGE LPRSPSPPPV PPPPASVPPY  60
   61 SPESSSFHLA SLQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [832-882]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKRQESNDSH CSDSTTHSQC TAINLASPPP PPTAQPPTPP LRQKPAPPPV P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [883-1031]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPVSPPAPPT PQSEPELSVA DSVANANADV DADADTDTEA IKKLRLLCTE QLASMPYGEQ  60
   61 VLEELASVAQ NISDQSQNKM PYPMPQLPHI KELQLNANES KSSSAWLGLP TQSDPKLLVC 120
  121 LSPGQRDLVN NQTQPDDLLD AHQKFVERR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1032-1242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYHELSKAQV LEQDHQQQQS EMLKTAAMMR ELRKSLSPPA PPVPPPPVPV KSAETAAKAT  60
   61 AHENAKRDDA SEQKQKIAAC ESSSLENKPR RAADLGAQQS AEQRQSSSTT TSSHKATTET 120
  121 MSSDTAKFPT LDSMESELAR MFPQHKGDIF EEQRKRFSNI EFPSHQPVSQ TKRYSNIETS 180
  181 SYESKKRMEN GQVVYDVSTS SHEKKEQGDP P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1243-1358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDQPVPPVPP PPIMSATKLN GNTFIDGDVA PKNSQPSRES GSGSGNGTYE EFRQRAKAAA  60
   61 DAFGEQREQQ NGLDQDRVFK DFDRLSQQMH AELQSTREKR EKSASMYDLS GFTRPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1359-1448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGHPRLDELQ QRRHAHMQEL EREIERSAKS RQERMSSVPR QMEATPPRTH EIPIELEPRS  60
   61 RRAESLCNLN EPPPRPHTTV GHYNHPVVQD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1449-1528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWSRYANDLG YSENIARPFA REVEICYQRQ NQRTPHCIRA PRLSASTNDL SSSSQYSYDT  60
   61 FNAYGGRRTH APMLNQAQQQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [1529-1733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRPHYGSCYS MIERDPNPRY ISTTSRRGVS PAPPPVATPQ QQQVPPPAYD RQQRRSSLPR  60
   61 ELHEQQLKYI LSKEEELKFE VERLQQERRR LMEEMQRAPV LPAPQRRESY RPAAKLPTLS 120
  121 EDEVFRQQMA EEWMNKVAER EERRQHKIIR ISKIEDEHDH SAVDKATISD EFLDRVKERR 180
  181 HKLSMPADSD WESGAESQPQ PAAQS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1734-1919]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPESDVEAPP VRILEGQAEA NLRQLPRHLR EFAKFSTSEQ LPDGAQMERH EEQERREEAT  60
   61 DNAHSSATKK TSIVKTYKVS RLPPSVQARP SYKSNGYVSE PEPNYDSDYS TVRYRTQNPH 120
  121 RVQSVSSAVN VRNLNQDEKL YGTMPNPIKS AQNSYKNQPG RIENYTTGHS SVSEKEKKEW 180
  181 WDEVMD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #15
Region A:
Residues: [1920-2110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFNGNLEQSK LSPLYTEGNL SRALAKESGY TSDSNLVFRK KEVPVSSPLS PVEQKQAYKS  60
   61 LQAGGEPPLL GFRKPAPEKP RDLDPNAPPI PPQPPVKGLS SYDFPYSTDT VDGSDVNIHF 120
  121 KTPIRHEQRQ NLSEEELAIR QAEHMQKLYH EERRRKYLQE LQDMNSRRHT DNFTPSQKSP 180
  181 IALNRYDDFP T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #16
Region A:
Residues: [2111-2185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVTLKSLVGP KTVARALFNF QGQTSKELSF RKGDTIYIRR QIDANWYEGE HNAMIGLLPA  60
   61 SYVEIVSRDG ARTPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.522879
Match: 1uecA
Description: p47pox (neutrophil cytosolic factor 1)
Matching Structure (courtesy of the PDB):

Predicted Domain #17
Region A:
Residues: [2186-2376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRPSEGQARA KYNFQAQSGI ELSLNKGELV TLTRRVDGNW FEGKIANRKG IFPCSYVEVL  60
   61 TDIGAEDIAA RTTTVITSQS TTNLRPNLDV LRTNINNEFN TLTQNGAQPP NGILKETRTL 120
  121 HKTDALHVDT SSEPLAYRAL YKYRPQNSDE LELLEGDVVH VLEKCDDGWF VGTSQRTGCF 180
  181 GTFPGNYVER A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13376047180398 bayes_pls_golite062009
protein binding 1.03382488697656 bayes_pls_golite062009
signal transducer activity 0.69727426993974 bayes_pls_golite062009
molecular transducer activity 0.69727426993974 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle