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View Structure Prediction Details

Protein: CAP-PA
Organism: Drosophila melanogaster
Length: 2376 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAP-PA.

Description E-value Query
Range
Subject
Range
gi|14669814 - gi|14669814|dbj|BAB62017.1| DCAPL1 [Drosophila melanogaster]
565.0 [0..1] [2376..1]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNNRNRNRN RNRNKRNRNQ NQNQNPSQNQ NENHQQQAEG AEDREEQQDF QTQIAVAQSS  60
   61 SFVDDNGNSG SVSNGPTENS EEVTNTLEKT EKKEEIFEQP ATVIQKEADS DAEMGAKNSK 120
  121 HRKEKSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [128-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQASNGKSEE QVRPPPTIIR RPPGSPRQAK VIVHRIVREE DTANGKAQSP EPPKAVESKE  60
   61 QHMEVEDSKK EKPEAQQEIE TKEERENEPS PKELPESSHL SEDAQQKHVE VEENQQVYDE 120
  121 VDYSKDETTD NNPQQEQHDS KEPEQYVLQL EKAMEFVENA HQQHVAAVQS YQKQRDTEQN 180
  181 AQQQEQNEAQ HLQESTKAHQ QNIAVPQILV DPKKREEGLA QQLHHD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [354-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKEEPILNNA QQQNDDTAPK SPKEVTIKVQ FQTEDPYSQQ PPPQKPTSKV IIHQIHVETT  60
   61 DEEQNAKPTF EEVSSTTGSL AGTLSPPPRY LVESPKNVSS GQFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [458-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFSRNVQIQE MELNSDFSSG EFNSLQSPLV CEVDSESEGS VVLGPERSPS DQQVPSSSRV  60
   61 EQHEQVRQKR AQYRNALESH FMPQLLNPRY LDSILEENEW RNSTASS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [565-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGSDQTGIRT PKLNETFPRS QLDFSRRHKR REEAPSPLKL ETKLLEESTD LESCTRLQSA  60
   61 LSPQSEDAEL VYLSSSASSS VSDLMELELE QAAALAERAL VDLDTDASRL IARPDDEMSS 120
  121 TSTTTADRSE TEAETETETE REGEQSREST PVNANPTLAS SQSSLLSAAT PTPTPTPTPA 180
  181 DREQLAKDTN VSGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [759-831]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STVSFGAASP LAATREEFVR NMDKVRELIE MTRREQEQGE LPRSPSPPPV PPPPASVPPY  60
   61 SPESSSFHLA SLQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [832-882]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKRQESNDSH CSDSTTHSQC TAINLASPPP PPTAQPPTPP LRQKPAPPPV P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [883-1031]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPVSPPAPPT PQSEPELSVA DSVANANADV DADADTDTEA IKKLRLLCTE QLASMPYGEQ  60
   61 VLEELASVAQ NISDQSQNKM PYPMPQLPHI KELQLNANES KSSSAWLGLP TQSDPKLLVC 120
  121 LSPGQRDLVN NQTQPDDLLD AHQKFVERR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1032-1242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYHELSKAQV LEQDHQQQQS EMLKTAAMMR ELRKSLSPPA PPVPPPPVPV KSAETAAKAT  60
   61 AHENAKRDDA SEQKQKIAAC ESSSLENKPR RAADLGAQQS AEQRQSSSTT TSSHKATTET 120
  121 MSSDTAKFPT LDSMESELAR MFPQHKGDIF EEQRKRFSNI EFPSHQPVSQ TKRYSNIETS 180
  181 SYESKKRMEN GQVVYDVSTS SHEKKEQGDP P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1243-1358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDQPVPPVPP PPIMSATKLN GNTFIDGDVA PKNSQPSRES GSGSGNGTYE EFRQRAKAAA  60
   61 DAFGEQREQQ NGLDQDRVFK DFDRLSQQMH AELQSTREKR EKSASMYDLS GFTRPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1359-1448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGHPRLDELQ QRRHAHMQEL EREIERSAKS RQERMSSVPR QMEATPPRTH EIPIELEPRS  60
   61 RRAESLCNLN EPPPRPHTTV GHYNHPVVQD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1449-1528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWSRYANDLG YSENIARPFA REVEICYQRQ NQRTPHCIRA PRLSASTNDL SSSSQYSYDT  60
   61 FNAYGGRRTH APMLNQAQQQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [1529-1733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRPHYGSCYS MIERDPNPRY ISTTSRRGVS PAPPPVATPQ QQQVPPPAYD RQQRRSSLPR  60
   61 ELHEQQLKYI LSKEEELKFE VERLQQERRR LMEEMQRAPV LPAPQRRESY RPAAKLPTLS 120
  121 EDEVFRQQMA EEWMNKVAER EERRQHKIIR ISKIEDEHDH SAVDKATISD EFLDRVKERR 180
  181 HKLSMPADSD WESGAESQPQ PAAQS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1734-1919]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPESDVEAPP VRILEGQAEA NLRQLPRHLR EFAKFSTSEQ LPDGAQMERH EEQERREEAT  60
   61 DNAHSSATKK TSIVKTYKVS RLPPSVQARP SYKSNGYVSE PEPNYDSDYS TVRYRTQNPH 120
  121 RVQSVSSAVN VRNLNQDEKL YGTMPNPIKS AQNSYKNQPG RIENYTTGHS SVSEKEKKEW 180
  181 WDEVMD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #15
Region A:
Residues: [1920-2110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFNGNLEQSK LSPLYTEGNL SRALAKESGY TSDSNLVFRK KEVPVSSPLS PVEQKQAYKS  60
   61 LQAGGEPPLL GFRKPAPEKP RDLDPNAPPI PPQPPVKGLS SYDFPYSTDT VDGSDVNIHF 120
  121 KTPIRHEQRQ NLSEEELAIR QAEHMQKLYH EERRRKYLQE LQDMNSRRHT DNFTPSQKSP 180
  181 IALNRYDDFP T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #16
Region A:
Residues: [2111-2185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVTLKSLVGP KTVARALFNF QGQTSKELSF RKGDTIYIRR QIDANWYEGE HNAMIGLLPA  60
   61 SYVEIVSRDG ARTPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.522879
Match: 1uecA
Description: p47pox (neutrophil cytosolic factor 1)
Matching Structure (courtesy of the PDB):

Predicted Domain #17
Region A:
Residues: [2186-2376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRPSEGQARA KYNFQAQSGI ELSLNKGELV TLTRRVDGNW FEGKIANRKG IFPCSYVEVL  60
   61 TDIGAEDIAA RTTTVITSQS TTNLRPNLDV LRTNINNEFN TLTQNGAQPP NGILKETRTL 120
  121 HKTDALHVDT SSEPLAYRAL YKYRPQNSDE LELLEGDVVH VLEKCDDGWF VGTSQRTGCF 180
  181 GTFPGNYVER A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13376047180398 bayes_pls_golite062009
protein binding 1.03382488697656 bayes_pls_golite062009
signal transducer activity 0.69727426993974 bayes_pls_golite062009
molecular transducer activity 0.69727426993974 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle