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View Structure Prediction Details

Protein: Aldh-III-PL, Ald...
Organism: Drosophila melanogaster
Length: 498 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Aldh-III-PL, Ald....

Description E-value Query
Range
Subject
Range
gi|52785994, gi|... - gi|52785994|ref|YP_091823.1| DhaS [Bacillus licheniformis ATCC 14580], gi|52348496|gb|AAU41130.1| Dh...
522.0 [0..2] [430..60]

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Predicted Domain #1
Region A:
Residues: [1-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANFDDTLQR ARLAFSSGKT RNVSFRRKQL ENLLRCYEEH ENEIISALEA DLRRPKQESL  60
   61 IVETEFMKND IRHILFQLDE WVQSEKPPKS FVNMMDDVQI YNDPFGVVLV IGAWNYPLQL 120
  121 LLVPVASAIA AGNCVVIKPS EIAANCAKFI ADVIPKYLDN DCYPVVCGGP SETAELLNQR 180
  181 FDYIFYTGST RVGKIIHAAA NKYLTPTTLE LGGKSPCYID KSVDMRTAVK RILWGKLINC 240
  241 GQTCIAPDYI LCSKEVQEKF IVEAKDVLKE WYGENIQSSP DLSRVINANN FQRLLGLMKS 300
  301 GRVAVGGNYD ASERFIEPTI LVDVKETDPI MEEEIFGPIL PIFNVESAYD AIKFINARES 360
  361 PLVLYIFTPT AEVQNLFING TQSGGLCVND TIMHYAVDVL PFGGVGMSGM GRYHGKYGFE 420
  421 TFTHKKSCLG KDLSPLGEKL SSARYPPYSD RKGSLLSFLL RKRRPLPNLH LSHVLAIGLG 480
  481 VGLTVLTNYY LQGKLLSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 117.0
Match: 1ad3A
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.09598561374689 bayes_pls_golite062009
oxidoreductase activity 4.47226217021998 bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity 3.87605237828483 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity 3.64672165191647 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 3.49281413016612 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 3.37049090049734 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2867555127991 bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity 2.81851373615334 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity 2.71501590413507 bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity 2.43250909158896 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.02102050611755 bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity 1.75951883819887 bayes_pls_golite062009
retinal dehydrogenase activity 1.42867174920845 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
retinoid binding 0.983782635681687 bayes_pls_golite062009
isoprenoid binding 0.900374761028287 bayes_pls_golite062009
protein binding 0.894945263794726 bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity 0.882678635212924 bayes_pls_golite062009
electron carrier activity 0.869224905025397 bayes_pls_golite062009
hydrolase activity 0.799513645745266 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity 0.23487570676521 bayes_pls_golite062009

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