YRC Public Data Repository - Protein Structure Prediction

Protein:	CG9960-PA
Organism:	Drosophila melanogaster
Length:	224 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG9960-PA.

Description	E-value	Query Range	Subject Range
PRMC_GEOSL - Release factor glutamine methyltransferase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 1212...	153.0	[0..1]	[217..81]
gi\|118504120, gi... - gi\|71839441\|ref\|ZP_00679190.1\| Modification methylase HemK [Pelobacter propionicus DSM 2379], gi\|717...	152.0	[0..1]	[219..80]
gi\|78221602, gi\|... - gi\|78221602\|ref\|YP_383349.1\| modification methylase HemK [Geobacter metallireducens GS-15], gi\|78192...	151.0	[0..1]	[217..81]
gi\|53732833 - gi\|53732833\|ref\|ZP_00349588.1\| COG2890: Methylase of polypeptide chain release factors [Haemophilus ... gi\|229847125, gi... - gi\|229847125\|ref\|ZP_04467230.1\| HemK [Haemophilus influenzae 7P49H1], gi\|229809954\|gb\|EEP45675.1\| He... gi\|148716241, gi... - gi\|148826081\|ref\|YP_001290834.1\| hypothetical protein CGSHiEE_05375 [Haemophilus influenzae PittEE],...	149.0	[0..1]	[219..75]
gi\|146399571, gi... - gi\|88936610\|ref\|ZP_01142215.1\| Modification methylase HemK [Geobacter uraniumreducens Rf4], gi\|88916...	148.0	[0..1]	[217..81]
gi\|20515121, gi\|... - gi\|20806671\|ref\|NP_621842.1\| rRNA or tRNA methylase [Thermoanaerobacter tengcongensis MB4], gi\|20515... gi\|20806671 - gi\|20806671\|ref\|NP_621842.1\| predicted rRNA or tRNA methylase [Thermoanaerobacter tengcongensis MB4]	148.0	[0..6]	[220..84]
gi\|78484733, gi\|... - gi\|78484733\|ref\|YP_390658.1\| HemK family modification methylase [Thiomicrospira crunogena XCL-2], gi...	147.0	[0..1]	[218..74]
gi\|196113152, gi... - gi\|88796062\|ref\|ZP_01111746.1\| peptide release factor-glutamine N5-methyltransferase [Alteromonas ma...	147.0	[0..1]	[218..72]
gi\|42631607 - gi\|42631607\|ref\|ZP_00157145.1\| COG2890: Methylase of polypeptide chain release factors [Haemophilus ... gi\|145639101, gi... - gi\|145639101\|ref\|ZP_01794709.1\| HemK [Haemophilus influenzae PittII], gi\|145272073\|gb\|EDK11982.1\| He...	146.0	[0..1]	[219..75]
gi\|241902910, gi... - gi\|241902910\|ref\|ZP_04787640.1\| modification methylase, HemK family [Thermoanaerobacter brockii subs... gi\|242256840, gi... - gi\|242256840\|ref\|ZP_04801723.1\| modification methylase, HemK family [Thermoanaerobacter sp. X513], g... gi\|167038766, gi... - gi\|167038766\|ref\|YP_001661751.1\| HemK family modification methylase [Thermoanaerobacter sp. X514], g... gi\|76795967, gi\|... - gi\|76795967\|ref\|ZP_00778337.1\| Modification methylase HemK [Thermoanaerobacter ethanolicus ATCC 3322...	144.0	[0..5]	[219..77]

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Predicted Domain #1

Region A:
Residues: [1-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPYTDHLS PEDFEHVYEP AEDSFLLLDA LEKDLEYLDR LQPSLCVELG SGSGVIITAL  60
   61 AKKLAGFSLC LATDINPKAC NATRRTATRN GARLDSIRCS LADALRPRSV DVLLFNPPYV 120
  121 VTSDEELQTQ QFDSHSESST DRNLVFSWAG GQDGRRVTDI LLKQLDDILS PRGVLYLLLL 180
  181 RENKPEEIIK YLEGLQFRAV KFMERRIPGE HLCILKVTRY LASS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.09691
Match:	1t43A
Description:	Crystal Structure Analysis of E.coli Protein (N5)-Glutamine Methyltransferase (HemK)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein methyltransferase activity	5.03267617653315	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	4.4632173842967	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
histone methyltransferase activity	3.97658336148086	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
transferase activity	2.926540904444	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.86617323549909	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	2.48017990451667	bayes_pls_golite062009
DNA-methyltransferase activity	2.18991764495147	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.91133457052099	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	1.69391860928068	bayes_pls_golite062009
transcription regulator activity	1.61435611638306	bayes_pls_golite062009
DNA binding	1.53375495589674	bayes_pls_golite062009
nucleic acid binding	1.31440474302645	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	1.15089820497406	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
protein binding	0.871386560666009	bayes_pls_golite062009
RNA methyltransferase activity	0.817509452491588	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
rRNA methyltransferase activity	0.230719796976667	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: