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View Structure Prediction Details

Protein: FGF14_RAT
Organism: Rattus norvegicus
Length: 247 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF14_RAT.

Description E-value Query
Range
Subject
Range
FGF14_MOUSE - Fibroblast growth factor 14 OS=Mus musculus GN=Fgf14 PE=2 SV=1
299.0 [0..1] [247..1]
gi|114650543 - gi|114650543|ref|XP_001150157.1| PREDICTED: fibroblast growth factor 14 isoform 1 [Pan troglodytes]
gi|109121204 - gi|109121204|ref|XP_001093573.1| PREDICTED: fibroblast growth factor 14 isoform 2 [Macaca mulatta]
FGF14 - fibroblast growth factor 14
297.0 [0..1] [247..1]
gi|6911133, gi|4... - gi|6911133|gb|AAF31398.1|AF199611_1 fibroblast growth factor homologous factor 2 isoform 1T+1S' [Gal...
284.0 [0..1] [247..1]
gi|190339590, gi... - gi|59933268|ref|NP_001012382.1| fibroblast growth factor 14 [Danio rerio], gi|56201432|dbj|BAD72888....
283.0 [0..1] [244..1]
gi|60811740, gi|... - gi|60825649|gb|AAX36728.1| fibroblast growth factor 13 [synthetic construct], gi|60811740|gb|AAX3618...
281.0 [0..1] [247..1]
gi|74008559 - gi|74008559|ref|XP_549294.2| PREDICTED: similar to fibroblast growth factor 13 isoform 1 [Canis fami...
281.0 [0..1] [247..1]

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Predicted Domain #1
Region A:
Residues: [1-60]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [61-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK  60
   61 TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ 120
  121 VMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP 180
  181 VNKCKTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.221849
Match: 1q1uA
Description: Crystal structure of human FHF1b (FGF12b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.30358117760805 bayes_pls_golite062009
growth factor activity 3.97089267530575 bayes_pls_golite062009
cytokine activity 3.76931834545338 bayes_pls_golite062009
binding 2.90110516688922 bayes_pls_golite062009
protein binding 1.94397222237906 bayes_pls_golite062009
fibroblast growth factor receptor binding 1.9437092554389 bayes_pls_golite062009
pattern binding 0.839280621598109 bayes_pls_golite062009
interleukin-1 receptor binding 0.8084616632765 bayes_pls_golite062009
glycosaminoglycan binding 0.69866345905635 bayes_pls_golite062009
heparin binding 0.290941670257021 bayes_pls_golite062009

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