YRC Public Data Repository - Protein Structure Prediction

Protein:	METL6_MOUSE
Organism:	Mus musculus
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METL6_MOUSE.

Description	E-value	Query Range	Subject Range
METL6_RAT - Methyltransferase-like protein 6 OS=Rattus norvegicus GN=Mettl6 PE=2 SV=1	202.0	[0..1]	[282..1]
gi\|114585570 - gi\|114585570\|ref\|XP_001159583.1\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]	198.0	[0..1]	[269..1]
METL6_PONPY - Methyltransferase-like protein 6 - Pongo pygmaeus (Orangutan) METL6_PONAB - Methyltransferase-like protein 6 OS=Pongo abelii GN=METTL6 PE=2 SV=1	191.0	[0..1]	[269..1]
gi\|109050643 - gi\|109050643\|ref\|XP_001082383.1\| PREDICTED: similar to methyltransferase like 6 isoform 1 [Macaca mu...	191.0	[0..1]	[273..1]
gi\|57103588 - gi\|57103588\|ref\|XP_534257.1\| PREDICTED: similar to ZK1058.5 [Canis familiaris]	187.0	[0..1]	[268..1]
gi\|123982406, gi... - gi\|123997065\|gb\|ABM86134.1\| methyltransferase like 6 [synthetic construct], gi\|123982406\|gb\|ABM82944... METTL6 - methyltransferase like 6	177.0	[0..1]	[255..1]
gi\|54641515, gi\|... - gi\|54641515\|gb\|EAL30265.1\| GA12634-PA [Drosophila pseudoobscura], gi\|125977464\|ref\|XP_001352765.1\| G...	177.0	[0..6]	[273..29]
gi\|50732822, gi\|... - gi\|50732822\|ref\|XP_418781.1\| PREDICTED: similar to RIKEN cDNA 1600013P15 [Gallus gallus], gi\|1180859...	176.0	[0..2]	[273..21]
gi\|112419026 - gi\|112419026\|gb\|AAI22481.1\| LOC733347 protein [Xenopus laevis]	173.0	[0..5]	[272..65]
gi\|115609797, gi... - gi\|115609797\|ref\|XP_001176656.1\| PREDICTED: similar to Methyltransferase like 2 [Strongylocentrotus ...	173.0	[0..10]	[269..106]

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Predicted Domain #1

Region A:
Residues: [1-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASFQRKGLQ ARILSTEEEE KLKRDQALVS AFKQQKLEKE AQKNWDLFYK RNSTNFFKDR  60
   61 HWTTREFEEL RSCREYEGQK LTLLEAGCGV GNCLFPLLEE DLNLFAYACD FSPRAVDYVK 120
  121 QHPLYNAERC KVFQCDLTRD DLLDHVPPES VDAVTLIFVL SAVHPEKMRL VLLNVYKVLK 180
  181 PGRSVLFRDY GLNDHAMLRF KAGSKLGENF YVRQDGTRSY FFTDEFLAQL FVDAGYEEVV 240
  241 NEYVFRETVN KKEGLCVPRV FLQSKFRKPP KDPAPTSDSA SL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.69897
Match:	2fk7A
Description:	Crystal structure of Hma (MmaA4) from Mycobacterium tuberculosis, apo-form
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity	1.55708326065545	bayes_pls_golite062009
protein methyltransferase activity	0.90417202530863	bayes_pls_golite062009
N-methyltransferase activity	0.89763572661057	bayes_pls_golite062009
binding	0.777596419415505	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.352072576393216	bayes_pls_golite062009
methyltransferase activity	0.349480046648587	bayes_pls_golite062009
histone methyltransferase activity	0.34836765632152	bayes_pls_golite062009
DNA binding	0.07821658818758	bayes_pls_golite062009
transcription regulator activity	0.073128297647348	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: