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View Structure Prediction Details

Protein: NTM1A_MOUSE
Organism: Mus musculus
Length: 223 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTM1A_MOUSE.

Description E-value Query
Range		 Subject
Range
NTM1A_RAT - N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Rattus norvegicus GN=Ntmt1 PE=2 SV=3
 174.0 [0..1] [223..1]
CCDS35160.1_1 - null
METTL11A - methyltransferase like 11A
gi|109110044, gi... - gi|109110046|ref|XP_001108216.1| PREDICTED: similar to CG1675-PA isoform 2 [Macaca mulatta], gi|1091...
 171.0 [0..1] [223..1]
gi|114627144, gi... - gi|55632451|ref|XP_520309.1| PREDICTED: similar to Chromosome 9 open reading frame 32 isoform 5 [Pan...
 169.0 [0..1] [223..1]
NTM1A_BOVIN - N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Bos taurus GN=NTMT1 PE=2 SV=3
 167.0 [0..1] [223..1]
gi|73967997 - gi|73967997|ref|XP_548421.2| PREDICTED: similar to CG1675-PA [Canis familiaris]
 164.0 [0..1] [223..23]
NT1AB_XENLA - N-terminal Xaa-Pro-Lys N-methyltransferase 1-B OS=Xenopus laevis GN=ntmt1-b PE=2 SV=1
 162.0 [0..1] [223..1]

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Predicted Domain #1
Region A:
Residues: [1-223] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISNI DLNSSRKFLQ RFLREGPNKT  60
   61 GTSCALDCGA GIGRITKRLL LPLFRVVDMV DVTEDFLAKA KTYLGEEGKR VRNYFCCGLQ 120
  121 DFSPEPGSYD VIWIQWVIGH LTDQHLAEFL RRCKRGLRPN GIIVIKDNMA QEGVILDDVD 180
  181 SSVCRDLEVV RRIIRTAGLS LLAEERQENL PDEIYHVYSF ALR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 2ex4A
Description: Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 3.57681394097837 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 3.49392219433935 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
rRNA methyltransferase activity 2.5924681776558 bayes_pls_golite062009
tRNA methyltransferase activity 1.76571145896453 bayes_pls_golite062009
N-methyltransferase activity 1.57269280784007 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
protein methyltransferase activity 0.94499223839747 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.794703281700029 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.716476158062361 bayes_pls_golite062009
DNA binding 0.71058003448013 bayes_pls_golite062009
nucleic acid binding 0.698509190696763 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 0.0854264678700428 bayes_pls_golite062009
histone methyltransferase activity 0.0408000230099101 bayes_pls_golite062009
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