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View Structure Prediction Details

Protein: gi|1172123, gi|1...
Organism: Mus musculus
Length: 240 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|1172123, gi|1....

Description E-value Query
Range
Subject
Range
gi|109077030 - gi|109077030|ref|XP_001094714.1| PREDICTED: similar to glial cell line derived neurotrophic factor [...
341.0 [0..1] [240..125]
gi|114600517 - gi|114600517|ref|XP_001143054.1| PREDICTED: similar to neurotrophic factor isoform 3 [Pan troglodyte...
gi|119576368 - gi|119576368|gb|EAW55964.1| glial cell derived neurotrophic factor, isoform CRA_b [Homo sapiens]
322.0 [0..21] [240..9]
gi|76646518 - gi|76646518|ref|XP_615361.2| PREDICTED: similar to glial cell line derived neurotrophic factor [Bos ...
313.0 [0..1] [240..119]
gi|73954307 - gi|73954307|ref|XP_546342.2| PREDICTED: similar to glial cell derived neurotrophic factor isoform 1 ...
312.0 [0..22] [240..47]
GDNF_MOUSE - Glial cell line-derived neurotrophic factor OS=Mus musculus GN=Gdnf PE=2 SV=1
310.0 [0..30] [240..1]
gi|50762337 - gi|50762337|ref|XP_425018.1| PREDICTED: similar to glial cell line-derived neurotrophic factor long ...
310.0 [0..30] [240..1]
gi|60826762 - gi|60826762|gb|AAX36770.1| glial cell derived neurotrophic factor [synthetic construct]
309.0 [0..30] [240..1]
gi|55624456 - gi|55624456|ref|XP_526944.1| PREDICTED: glial cell derived neurotrophic factor isoform 4 [Pan troglo...
gi|208968461 - gi|208968461|dbj|BAG74069.1| glial cell derived neurotrophic factor [synthetic construct]
GDNF - glial cell derived neurotrophic factor
309.0 [0..30] [240..1]
GDNF_RAT - Glial cell line-derived neurotrophic factor OS=Rattus norvegicus GN=Gdnf PE=1 SV=1
306.0 [0..30] [240..1]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFGPLGVNV QLGVYGDRIR GAAAGRDSKM KLWDVVAVCL VLLHTASAFP LPAGKRLLEA  60
   61 PAEDHSLGHR RVPFALTSDS NMPEDYPDQF DDVM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [95-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFIQATIKRL KRSPDKQAAA LPRRERNRQA AAASPENSRG KGRRGQRGKN RGCVLTAIHL  60
   61 NVTDLGLGYE TKEELIFRYC SGSCESAETM YDKILKNLSR SRRLTSDKVG QACCRPVAFD 120
  121 DDLSFLDDNL VYHILRKHSA KRCGCI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.221849
Match: 1agqA
Description: Glial cell-derived neurotrophic factor, GDNF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
vascular endothelial growth factor receptor 1 binding 4.88004110368356 bayes_pls_golite062009
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 4.199474917569 bayes_pls_golite062009
growth factor activity 4.01406832911234 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 3.16494996397951 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 3.0813162230094 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 3.06631842262117 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
hormone activity 2.10500409590202 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.78479767888975 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
fibronectin binding 1.3732716084502 bayes_pls_golite062009
platelet-derived growth factor binding 1.18476084022243 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
collagen binding 1.00551310632663 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.772832351269279 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
transcription activator activity 0.290946570822357 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
signal transducer activity 0.102347067903142 bayes_pls_golite062009
molecular transducer activity 0.102347067903142 bayes_pls_golite062009
transcription regulator activity 0.0706173408709216 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle