YRC Public Data Repository - Protein Structure Prediction

Protein:	COTL1_MOUSE
Organism:	Mus musculus
Length:	142 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COTL1_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|48374972 - gi\|48374972\|gb\|AAT42170.1\| putative actin depolymerizing factor [Sorghum bicolor]	161.0	[0..1]	[129..332]
ADF1_ARATH - Actin-depolymerizing factor 1 OS=Arabidopsis thaliana GN=ADF1 PE=1 SV=1 gi\|195604826 - gi\|195604826\|gb\|ACG24243.1\| hypothetical protein [Zea mays]	150.0	[0..1]	[130..8]
ADF1_PETHY - Actin-depolymerizing factor 1 OS=Petunia hybrida GN=ADF1 PE=2 SV=1	150.0	[0..1]	[130..8]
gi\|38564721 - gi\|38564721\|gb\|AAR23800.1\| putative actin-depolymerizing factor 2 [Helianthus annuus]	149.0	[0..1]	[130..8]
gi\|109105452 - gi\|109105452\|ref\|XP_001118077.1\| PREDICTED: similar to Cofilin-1 (Cofilin, non-muscle isoform) (18 k...	149.0	[0..1]	[135..306]
gi\|106879609 - gi\|106879609\|emb\|CAJ38388.1\| actin-depolymerizing factor [Plantago major]	149.0	[0..1]	[130..8]
gi\|84028521 - gi\|84028521\|gb\|ABC49719.1\| actin depolymerizing factor-like protein [Arachis hypogaea]	149.0	[0..1]	[130..8]
ADF_LILLO - Actin-depolymerizing factor OS=Lilium longiflorum PE=2 SV=1	148.0	[0..1]	[129..8]

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Predicted Domain #1

Region A:
Residues: [1-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKIDKEAC RAAYNLVRDD GSAVIWVTFR YDGATIVPGD QGADYQHFIQ QCTDDVRLFA  60
   61 FVRFTTGDAM SKRSKFALIT WIGEDVSGLQ RAKTGTDKTL VKEVVQNFAK EFVISDRKEL 120
  121 EEDFIRSELK KAGGANYDAQ SE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.69897
Match:	1udmA
Description:	Solution structure of Coactosin-like protein (Cofilin family) from Mus Musculus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	7.52071741004022	bayes_pls_golite062009
cytoskeletal protein binding	6.04859625643932	bayes_pls_golite062009
actin filament binding	5.45532510538573	bayes_pls_golite062009
binding	2.41877859618486	bayes_pls_golite062009
protein binding	1.87981807141519	bayes_pls_golite062009
structural constituent of cytoskeleton	0.482954032096802	bayes_pls_golite062009
structural molecule activity	0.391701411061931	bayes_pls_golite062009
actin monomer binding	0.224304003054399	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: