YRC Public Data Repository - Protein Structure Prediction

Protein:	MED21_MOUSE
Organism:	Mus musculus
Length:	144 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED21_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|50729132 - gi\|50729132\|ref\|XP_416442.1\| PREDICTED: similar to SRB7 suppressor of RNA polymerase B homolog; RNA ...	211.0	[0..1]	[144..191]
gi\|15126724 - gi\|15126724\|gb\|AAH12286.1\| Med21 protein [Mus musculus]	191.0	[0..1]	[144..1]
gi\|114645559 - gi\|114645559\|ref\|XP_001143632.1\| PREDICTED: SRB7 suppressor of RNA polymerase B homolog isoform 1 [P... MED21 - mediator complex subunit 21 gi\|208966724, gi... - gi\|208966724\|dbj\|BAG73376.1\| mediator complex subunit 21 [synthetic construct], gi\|167774049\|gb\|ABZ9...	190.0	[0..1]	[144..1]
tr\|M3X3Y9\|M3X3Y9... - Mediator complex subunit 21 OS=Felis catus GN=MED21 PE=4 SV=1 gi\|149714050 - gi\|149714050\|ref\|XP_001502847.1\| PREDICTED: similar to SRB7 [Equus caballus] gi\|73996918 - gi\|73996918\|ref\|XP_852318.1\| PREDICTED: similar to SRB7 suppressor of RNA polymerase B homolog isofo...	189.0	[0..1]	[144..1]
gi\|149048956, gi... - gi\|27713629\|ref\|XP_232531.1\| PREDICTED: similar to SRB7 (supressor of RNA polymerase B) homolog [Rat...	188.0	[0..1]	[144..1]
MED21_MACFA - Mediator of RNA polymerase II transcription subunit 21 OS=Macaca fascicularis GN=MED21 PE=2 SV=1 CCDS8711.1_1 - null gi\|109096038 - gi\|109096038\|ref\|XP_001099368.1\| PREDICTED: similar to SRB7 suppressor of RNA polymerase B homolog [...	187.0	[0..1]	[144..1]
gi\|55726383 - gi\|55726383\|emb\|CAH89961.1\| hypothetical protein [Pongo abelii] MED21_PONAB - Mediator of RNA polymerase II transcription subunit 21 OS=Pongo abelii GN=MED21 PE=2 SV=1	187.0	[0..1]	[144..1]
MED21_BOVIN - Mediator of RNA polymerase II transcription subunit 21 OS=Bos taurus GN=MED21 PE=2 SV=1	186.0	[0..1]	[144..1]

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Predicted Domain #1

Region A:
Residues: [1-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFSNIQT AINKDQPANP TEEYAQLFAA  60
   61 LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA ATCLEDVVYR GDMLLEKIQS 120
  121 ALADIAQSQL KTRSVTHSHS LPDS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.69897
Match:	1ykeB
Description:	Structure of the mediator MED7/MED21 subcomplex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	10.1183123619291	bayes_pls_golite062009
RNA polymerase II transcription mediator activity	9.09831709949274	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.91274983688069	bayes_pls_golite062009
transcription regulator activity	3.80634349950328	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: