YRC Public Data Repository - Protein Structure Prediction

Protein:	TFPI2_MOUSE
Organism:	Mus musculus
Length:	230 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFPI2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|50732495 - gi\|50732495\|ref\|XP_418662.1\| PREDICTED: similar to MGC68843 protein [Gallus gallus]	195.0	[0..32]	[213..167]
gi\|33416634, gi\|... - gi\|33416634\|gb\|AAH55972.1\| MGC68843 protein [Xenopus laevis], gi\|147900418\|ref\|NP_001079835.1\| hypot...	192.0	[0..10]	[225..4]
gi\|23477189, gi\|... - gi\|27465613\|ref\|NP_775164.1\| tissue factor pathway inhibitor 2 [Rattus norvegicus], gi\|23477189\|emb\|...	192.0	[0..1]	[230..1]
gi\|58477071, gi\|... - gi\|62751741\|ref\|NP_001015766.1\| MGC108301 protein [Xenopus (Silurana) tropicalis], gi\|58477071\|gb\|AA...	190.0	[0..9]	[214..2]
gi\|110756487 - gi\|110756487\|ref\|XP_396472.3\| PREDICTED: similar to Papilin CG33103-PB, isoform B isoform 1 [Apis me...	187.0	[0..23]	[230..1656]
gi\|157124198, gi... - gi\|157124198\|ref\|XP_001660360.1\| papilin [Aedes aegypti], gi\|108874079\|gb\|EAT38304.1\| papilin [Aedes...	186.0	[0..23]	[230..1524]
gi\|6164595 - gi\|6164595\|gb\|AAF04457.1\|AF078161_1 lacunin [Manduca sexta]	182.0	[0..19]	[229..2056]
TFPI1_MACMU - Tissue factor pathway inhibitor OS=Macaca mulatta GN=TFPI PE=2 SV=1	182.0	[0..1]	[217..5]
gi\|63101416 - gi\|63101416\|gb\|AAH94984.1\| Tfpia protein [Danio rerio]	181.0	[0..4]	[220..15]
gi\|22901764 - gi\|22901764\|gb\|AAN10061.1\| Kunitz-like protease inhibitor precursor [Ancylostoma caninum]	180.0	[0..23]	[229..254]

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Predicted Domain #1

Region A:
Residues: [1-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPAMPLQLW NLPLLLVGSV LGLTSVSAQG NNLEICLLPL DAGPCQALIP KFYYDRDQQK  60
   61 CRRFNYGGCL GNANNFHSRD LCQQTCGSIE KVPPVCRSEL KTYPCDKPNI RFFFNLNTMT 120
  121 CEPLRPGLCS RTINVFSEEA TCKGLCEPRK HIPSFCSSPK DE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.0
Match:	1bikA
Description:	X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase inhibitor activity	0.25293549040514	bayes_pls_golite062009
extracellular matrix structural constituent	0.20228830453365	bayes_pls_golite062009
enzyme inhibitor activity	0.0325480717581303	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [163-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLCSANVTRF YFNSRNKTCE TFTYTGCGGN ENNFYYLDAC HRACVKGWKK PKRWKIGDFL  60
   61 PRFWKHLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.69897
Match:	1aapA
Description:	Alzheimer's amyloid B-protein precursor, APPI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase inhibitor activity	0.25293549040514	bayes_pls_golite062009
extracellular matrix structural constituent	0.20228830453365	bayes_pls_golite062009
enzyme inhibitor activity	0.0325480717581303	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: