YRC Public Data Repository - Protein Structure Prediction

Protein:	ONCM_MOUSE
Organism:	Mus musculus
Length:	263 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ONCM_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|74212785 - gi\|74212785\|dbj\|BAE33358.1\| unnamed protein product [Mus musculus]	380.0	[0..21]	[263..21]
ONCM_RAT - Oncostatin-M OS=Rattus norvegicus GN=Osm PE=2 SV=1 gi\|55741439 - ref\|NP_001006962.1\| oncostatin M [Rattus norvegicus]	347.0	[0..21]	[224..22]
gi\|60834962 - gi\|60834962\|gb\|AAX37118.1\| oncostatin M [synthetic construct]	337.0	[0..6]	[228..7]
OSM - oncostatin M gi\|109451408, gi... - gi\|208965308\|dbj\|BAG72668.1\| oncostatin M [synthetic construct], gi\|123998145\|gb\|ABM86674.1\| oncosta... HGNC:8506\|MIM:16... - M, M	336.0	[0..6]	[228..7]
gi\|114685834 - gi\|114685834\|ref\|XP_001136178.1\| PREDICTED: similar to Oncostatin M precursor (OSM) [Pan troglodytes...	336.0	[0..6]	[228..7]
gi\|109093951 - gi\|109093951\|ref\|XP_001110148.1\| PREDICTED: similar to oncostatin M precursor [Macaca mulatta]	311.0	[0..6]	[228..7]
gi\|73995418 - gi\|73995418\|ref\|XP_854737.1\| PREDICTED: similar to oncostatin M precursor [Canis familiaris]	290.0	[0..11]	[228..33]
ONCM_BOVIN - Oncostatin-M OS=Bos taurus GN=OSM PE=3 SV=1	283.0	[0..3]	[241..4]

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Predicted Domain #1

Region A:
Residues: [1-263]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTRLLRTLL SLTLSLLILS MALANRGCSN SSSQLLSQLQ NQANLTGNTE SLLEPYIRLQ  60
   61 NLNTPDLRAA CTQHSVAFPS EDTLRQLSKP HFLSTVYTTL DRVLYQLDAL RQKFLKTPAF 120
  121 PKLDSARHNI LGIRNNVFCM ARLLNHSLEI PEPTQTDSGA SRSTTTPDVF NTKIGSCGFL 180
  181 WGYHRFMGSV GRVFREWDDG STRSRRQSPL RARRKGTRRI RVRHKGTRRI RVRRKGTRRI 240
  241 WVRRKGSRKI RPSRSTQSPT TRA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.0
Match:	1evsA
Description:	Oncostatin M
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytokine receptor binding	4.13428560691736	bayes_pls_golite062009
protein binding	2.80193303735459	bayes_pls_golite062009
receptor binding	2.70174355570175	bayes_pls_golite062009
binding	2.04439164026078	bayes_pls_golite062009
cytokine activity	1.84881320597077	bayes_pls_golite062009
prolactin receptor binding	1.2868139478039	bayes_pls_golite062009
leukemia inhibitory factor receptor binding	1.11070444913352	bayes_pls_golite062009
growth factor activity	0.78922821641918	bayes_pls_golite062009
transcription regulator activity	0.692469067627199	bayes_pls_golite062009
catalytic activity	0.616609227147587	bayes_pls_golite062009
ciliary neurotrophic factor receptor binding	0.39114105657104	bayes_pls_golite062009
interleukin-6 receptor binding	0.22257927816942	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: