YRC Public Data Repository - Protein Structure Prediction

Protein:	LYPA1_MOUSE
Organism:	Mus musculus
Length:	230 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYPA1_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|109086409 - gi\|109086409\|ref\|XP_001083287.1\| PREDICTED: lysophospholipase I isoform 2 [Macaca mulatta]	187.0	[0..1]	[230..1]
LYPA1_PONPY - Acyl-protein thioesterase 1 - Pongo pygmaeus (Orangutan) LYPA1_PONAB - Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1	187.0	[0..1]	[230..1]
gi\|123996083, gi... - gi\|123996083\|gb\|ABM85643.1\| lysophospholipase I [synthetic construct], gi\|123981248\|gb\|ABM82453.1\| l... LYPLA1 - lysophospholipase I	186.0	[0..1]	[230..1]
gi\|114620143 - gi\|114620143\|ref\|XP_519760.2\| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes]	186.0	[0..1]	[230..1]
gi\|31127307 - gi\|31127307\|gb\|AAH52848.1\| Lysophospholipase 1 [Mus musculus]	183.0	[0..1]	[230..1]
gi\|49118340, gi\|... - gi\|49118340\|gb\|AAH73342.1\| MGC80756 protein [Xenopus laevis], gi\|148232361\|ref\|NP_001085785.1\| MGC80...	183.0	[0..1]	[230..1]
gi\|50737613 - gi\|50737613\|ref\|XP_419203.1\| PREDICTED: similar to Acyl-protein thioesterase 1 (Lysophospholipase I)...	182.0	[0..1]	[230..1]
gi\|89266935 - gi\|89266935\|emb\|CAJ81346.1\| lysophospholipase I [Xenopus tropicalis]	181.0	[0..1]	[230..1]

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Predicted Domain #1

Region A:
Residues: [1-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGNNMSAPM PAVVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIKSPHIK YICPHAPVMP  60
   61 VTLNMNMAMP SWFDIVGLSP DSQEDESGIK QAAETVKALI DQEVKNGIPS NRIILGGFSQ 120
  121 GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFSQGPINSA NRDISVLQCH GDCDPLVPLM 180
  181 FGSLTVERLK ALINPANVTF KIYEGMMHSS CQQEMMDVKH FIDKLLPPID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.69897
Match:	1fj2A
Description:	Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.24106351016868	bayes_pls_golite062009
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.09488027320166	bayes_pls_golite062009
lipase activity	0.849473630399459	bayes_pls_golite062009
carboxylesterase activity	0.424330502936163	bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity	0.277033874372149	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: