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View Structure Prediction Details

Protein: VPS91_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 537 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS91_SCHPO.

Description E-value Query
Range
Subject
Range
gi|42546399, gi|... - gi|46107396|ref|XP_380757.1| hypothetical protein FG00581.1 [Gibberella zeae PH-1], gi|42546399|gb|E...
365.0 [0..27] [445..301]
gi|50758176 - gi|50758176|ref|XP_415796.1| PREDICTED: similar to Rab5 GDP/GTP exchange factor, Rabex5 [Gallus gall...
363.0 [0..2] [461..170]
gi|114613805 - gi|114613805|ref|XP_519132.2| PREDICTED: RAB guanine nucleotide exchange factor (GEF) 1 [Pan troglod...
362.0 [0..2] [461..380]
ENSPTRT00000055439 - null
gi|61359644, gi|... - gi|61359653|gb|AAX41748.1| RAB guanine nucleotide exchange factor [synthetic construct], gi|61359644...
gi|6013006, gi|3... - gi|77176717|gb|ABA64473.1| RAP1 [Homo sapiens], gi|7657496|ref|NP_055319.1| RAB guanine nucleotide e...
358.0 [0..2] [461..42]
gi|61369698, gi|... - gi|61369703|gb|AAX43377.1| RAB guanine nucleotide exchange factor 1 [synthetic construct], gi|613696...
358.0 [0..2] [461..42]
gi|39940934, gi|... - gi|39940934|ref|XP_360004.1| hypothetical protein MG05379.4 [Magnaporthe grisea 70-15], gb|EAA54587....
353.0 [0..17] [462..273]
gi|73957603 - gi|73957603|ref|XP_536834.2| PREDICTED: similar to RAB guanine nucleotide exchange factor (GEF) 1 is...
351.0 [0..2] [461..42]
RABX5_BOVIN - Rab5 GDP/GTP exchange factor OS=Bos taurus GN=RABGEF1 PE=1 SV=1
351.0 [0..2] [461..42]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYPSFHEDP TKDESTVAEQ RKGQSNEEKP LIDLNDSLDE QRNAYNEHCK NHDQQPSQQV  60
   61 RNMEDEANQY EQTDSSSDQE VMNEKQSLDK ENRNDNIPHE NNPGQQEINE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [111-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIFDFHMFLE QLRSSSAEPV AKYLKSFLSE FTKRRWTVNY QVKLIRDFLK FINEKIEQYE  60
   61 PWASGSQAEI DNAKEGMEKL VLNRLYTSLF SPEIAKSGIP LSSEHSDDVE EDRVLSEKME 120
  121 LFQWITEENL DIKKQKSSSK FFKLAADELR RINDYHAPRD KIICLLNCCK VIFSYLRNVV 180
  181 KEESADMFVP ILIFVVLQAR PAHLVSNIQY IQRFRSPEKL TGEVMYYLST LMGAMSFIET 240
  241 LDCSSLTITE EEFNAQIEKS IKKMEERKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.30103
Match: 1txuA
Description: Crystal Structure of the Vps9 Domain of Rabex-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.53503231216012 bayes_pls_golite062009
GTPase activating protein binding 1.51214503459935 bayes_pls_golite062009
binding 1.43845202356718 bayes_pls_golite062009
enzyme regulator activity 0.345541740813359 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.275905530501797 bayes_pls_golite062009
GTPase regulator activity 0.242420370175624 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.180034469254504 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [380-537]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEKSESKTAV NENATYKDPV LSRGLSSSID VSTGVALVNL PEELENMKYL QIDTPESKEY  60
   61 PRSTRPRALL IVALSQLILE KDHAETQTSM LVLAIDLPIE YLVHIPRLLP ILPSFMKSSQ 120
  121 WMMDYNKMMT CERQQQRLLR QLKLKGYKLG KRLKQLRL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle