YRC Public Data Repository - Protein Structure Prediction

Protein:	NRTN_MOUSE
Organism:	Mus musculus
Length:	195 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NRTN_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|6716573 - gi\|6716573\|gb\|AAF26684.1\| glial cell line-derived neurotrophic factor long form [Gallus gallus]	234.0	[0..19]	[194..32]
gi\|119576367 - gi\|119576367\|gb\|EAW55963.1\| glial cell derived neurotrophic factor, isoform CRA_a [Homo sapiens] gi\|114600519 - gi\|114600519\|ref\|XP_001142907.1\| PREDICTED: similar to astrocyte-derived trophic factor 1, ATF-1 iso...	228.0	[0..23]	[195..24]
gi\|114600522 - gi\|114600522\|ref\|XP_001142981.1\| PREDICTED: glial cell derived neurotrophic factor isoform 2 [Pan tr... gi\|914287, gi\|40... - gi\|914287\|gb\|AAB33493.1\| astrocyte-derived trophic factor 1, ATF-1 [human, caudate, Peptide, 185 aa]...	228.0	[0..23]	[195..7]
gi\|4093183 - gi\|4093183\|gb\|AAC99782.1\| neurotrophic factor [Macaca mulatta]	228.0	[0..42]	[195..1]
gi\|149028170, gi... - gi\|39930493\|ref\|NP_445851.1\| neurturin [Rattus norvegicus], gi\|28195703\|gb\|AAO27768.1\| neurturin [Ra...	222.0	[0..1]	[195..1]
gi\|1172123, gi\|1... - gi\|7110601\|ref\|NP_034405.1\| glial cell line derived neurotrophic factor [Mus musculus], gi\|1669571\|d...	219.0	[0..24]	[195..62]
gi\|73987274 - gi\|73987274\|ref\|XP_542143.2\| PREDICTED: similar to Neurturin precursor [Canis familiaris]	218.0	[0..1]	[195..65]

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Predicted Domain #1

Region A:
Residues: [1-195]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRWKAAALV SLICSSLLSV WMCQEGLLLG HRLGPALAPL RRPPRTLDAR IARLAQYRAL  60
   61 LQGAPDAVEL RELSPWAARI PGPRRRAGPR RRRARPGARP CGLRELEVRV SELGLGYTSD 120
  121 ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR RVRRERARAH PCCRPTAYED EVSFLDVHSR 180
  181 YHTLQELSAR ECACV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.221849
Match:	1agqA
Description:	Glial cell-derived neurotrophic factor, GDNF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor serine/threonine kinase binding	4.27815942287831	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding	4.14014703177357	bayes_pls_golite062009
transforming growth factor beta receptor binding	4.14014703177357	bayes_pls_golite062009
type II transforming growth factor beta receptor binding	3.8943658126028	bayes_pls_golite062009
receptor binding	2.8479912121811	bayes_pls_golite062009
binding	2.64101807129423	bayes_pls_golite062009
protein binding	2.36794464190805	bayes_pls_golite062009
growth factor activity	1.8892192272657	bayes_pls_golite062009
vascular endothelial growth factor receptor binding	0.801389802382386	bayes_pls_golite062009
growth factor binding	0.772327486125282	bayes_pls_golite062009
molecular transducer activity	0.721924896985173	bayes_pls_golite062009
signal transducer activity	0.721924896985173	bayes_pls_golite062009
protein dimerization activity	0.697058311884552	bayes_pls_golite062009
protein homodimerization activity	0.344090347736442	bayes_pls_golite062009
cell surface binding	0.296497146463694	bayes_pls_golite062009
cytokine activity	0.284134661359739	bayes_pls_golite062009
identical protein binding	0.273591586673912	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: