YRC Public Data Repository - Protein Structure Prediction

Protein:	PP2C3_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	414 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PP2C3_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|609658 - gi\|609658\|gb\|AAA67321.1\| protein phosphatase 2C (ptc3+) [Schizosaccharomyces pombe]	422.0	[0..1]	[414..1]
gi\|32406686, gi\|... - gi\|32406686\|ref\|XP_323956.1\| hypothetical protein [Neurospora crassa], gi\|28950040\|emb\|CAD70795.1\| p... gi\|85091318 - gi\|85091318\|ref\|XP_958843.1\| hypothetical protein NCU04600 [Neurospora crassa OR74A]	354.0	[0..1]	[411..1]
gi\|33087518 - gi\|33087518\|gb\|AAP92916.1\| putative serine/threonine phosphatase 2C ptc2 [Hypocrea jecorina]	352.0	[0..1]	[411..1]
gi\|46137447, gi\|... - gi\|46137447\|ref\|XP_390415.1\| hypothetical protein FG10239.1 [Gibberella zeae PH-1], gi\|42547239\|gb\|E...	350.0	[0..1]	[411..1]
gi\|38109901, gi\|... - gi\|39951417\|ref\|XP_363425.1\| hypothetical protein MG01351.4 [Magnaporthe grisea 70-15], gb\|EAA55700....	345.0	[0..1]	[414..1]
gi\|116179784, gi... - gi\|88184817\|gb\|EAQ92285.1\| hypothetical protein CHGG_00520 [Chaetomium globosum CBS 148.51], gi\|1161...	338.0	[0..1]	[411..1]
PP2C2_SCHPO - Protein phosphatase 2C homolog 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ptc2 PE=3... ptc2 - protein phosphatase 2C Ptc2	333.0	[0..1]	[359..1]
gi\|46100372, gi\|... - gi\|71020473\|ref\|XP_760467.1\| hypothetical protein UM04320.1 [Ustilago maydis 521], ref\|XP_401935.1\| ...	329.0	[0..1]	[412..1]
gi\|115402127, gi... - gi\|115402127\|ref\|XP_001217140.1\| hypothetical protein ATEG_08554 [Aspergillus terreus NIH2624], gi\|1...	317.0	[0..1]	[327..1]
gi\|68303911 - gi\|68303911\|gb\|AAY89642.1\| PPM1B beta isoform variant 6 [Homo sapiens]	316.0	[0..1]	[389..1]

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Predicted Domain #1

Region A:
Residues: [1-414]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQTLSEPVT EKHSVNGSNE FVLYGLSSMQ GWRISMEDAH SAILSMECSA VKDPVDFFAV  60
   61 YDGHGGDKVA KWCGSNLPQI LEKNPDFQKG DFVNALKSSF LNADKAILDD DQFHTDPSGC 120
  121 TATVVLRVGN KLYCANAGDS RTVLGSKGIA KPLSADHKPS NEAEKARICA AGGFVDFGRV 180
  181 NGNLALSRAI GDFEFKNSNL EPEKQIVTAL PDVVVHEITD DDEFVVLACD GIWDCKTSQQ 240
  241 VIEFVRRGIV AGTSLEKIAE NLMDNCIASD TETTGLGCDN MTVCIVALLQ ENDKSAWYKK 300
  301 IADRVAANDG PCAPPEYAEN HGPGWRSGDN NKKVIVPPNF HQVKLNGSDG YDKDANENSK 360
  361 EDDSTNGSLA AGFRWKEHFF PHKAEEENSS SETDIVNSNK DVADDHKEAV SAAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.30103
Match:	1a6qA
Description:	CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.29765002420868	bayes_pls_golite062009
phosphatase activity	6.84540130415879	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.63839066304808	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.76293366458633	bayes_pls_golite062009
protein serine/threonine phosphatase activity	5.66354576593165	bayes_pls_golite062009
hydrolase activity	2.5631136269171	bayes_pls_golite062009
binding	1.74689317666387	bayes_pls_golite062009
catalytic activity	1.53401212718168	bayes_pls_golite062009
protein binding	0.425331902048676	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: