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View Structure Prediction Details

Protein: CNTF_MOUSE
Organism: Mus musculus
Length: 198 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNTF_MOUSE.

Description E-value Query
Range
Subject
Range
CNTF_PIG - Ciliary neurotrophic factor OS=Sus scrofa GN=CNTF PE=2 SV=1
286.0 [0..1] [196..1]
gi|109106105 - gi|109106105|ref|XP_001093229.1| PREDICTED: ciliary neurotrophic factor [Macaca mulatta]
282.0 [0..1] [195..1]
CNTF - ciliary neurotrophic factor
280.0 [0..1] [195..1]
CNTF_RAT - Ciliary neurotrophic factor OS=Rattus norvegicus GN=Cntf PE=1 SV=1
280.0 [0..1] [196..1]
CNTF_RABIT - Ciliary neurotrophic factor OS=Oryctolagus cuniculus GN=CNTF PE=1 SV=1
276.0 [0..1] [198..1]
gi|73995416 - gi|73995416|ref|XP_534732.2| PREDICTED: similar to Leukemia inhibitory factor precursor (LIF) (Diffe...
242.0 [0..11] [176..39]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL DSVDGVPVAS  60
   61 TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP TEGDFHQAIH TLTLQVSAFA 120
  121 YQLEELMALL EQKVPEKEAD GMPVTIGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRVIS 180
  181 SHHMGISAHE SHYGAKQM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.522879
Match: 1cnt1
Description: Ciliary neurotrophic factor (CNTF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.1883241815362 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
protein binding 3.52041127390038 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 3.41894439248144 bayes_pls_golite062009
binding 3.38401550405066 bayes_pls_golite062009
growth hormone activity 2.60130826123596 bayes_pls_golite062009
hormone activity 2.52921243340076 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
interleukin-27 binding 1.83998174953013 bayes_pls_golite062009
transcription regulator activity 1.46377724038658 bayes_pls_golite062009
interleukin-10 receptor binding 1.27984955354659 bayes_pls_golite062009
erythropoietin receptor binding 0.77580300541347 bayes_pls_golite062009
molecular transducer activity 0.470106824402923 bayes_pls_golite062009
signal transducer activity 0.470106824402923 bayes_pls_golite062009
interleukin-12 binding 0.32382333549078 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009

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