YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|74189424, gi\|...
Organism:	Mus musculus
Length:	281 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|74189424, gi|....

Description	E-value	Query Range	Subject Range
gi\|109066667 - gi\|109066667\|ref\|XP_001088000.1\| PREDICTED: similar to HUS1 checkpoint protein [Macaca mulatta]	409.0	[0..1]	[281..1]
gi\|114613293 - gi\|114613293\|ref\|XP_519090.2\| PREDICTED: HUS1 checkpoint protein isoform 2 [Pan troglodytes] HUS1 - HUS1 checkpoint homolog (S. pombe) gi\|208966516, gi... - gi\|61356098\|gb\|AAX41208.1\| HUS1 checkpoint-like [synthetic construct], gi\|61356089\|gb\|AAX41207.1\| HU...	408.0	[0..1]	[281..1]
gi\|54695830, gi\|... - gi\|61365947\|gb\|AAX42789.1\| HUS1 checkpoint-like [synthetic construct], gi\|54695830\|gb\|AAV38287.1\| HU...	407.0	[0..1]	[281..1]
gi\|149016928, gi... - gi\|157819027\|ref\|NP_001102562.1\| HUS1 checkpoint homolog [Rattus norvegicus], gi\|149016930\|gb\|EDL760...	406.0	[0..1]	[281..1]
gi\|119891181, gi... - gi\|76615586\|ref\|XP_591945.2\| PREDICTED: similar to HUS1 checkpoint protein isoform 1 [Bos taurus], g...	393.0	[0..1]	[281..1]
HUS1_MOUSE - Checkpoint protein HUS1 OS=Mus musculus GN=Hus1 PE=2 SV=1	392.0	[0..1]	[281..1]
gi\|30060007, gi\|... - gi\|30060007\|gb\|AAP13340.1\| PCNA-like DNA checkpoint protein Hus1 [Xenopus laevis], gi\|22038051\|gb\|AA...	382.0	[0..1]	[281..1]
gi\|55742140 - ref\|NP_001006827.1\| HUS1 checkpoint homolog [Xenopus tropicalis] gi\|55742140, gi\|... - gi\|55742140\|ref\|NP_001006827.1\| HUS1 checkpoint homolog [Xenopus (Silurana) tropicalis], gi\|49904210...	379.0	[0..1]	[281..1]
gi\|114613295 - gi\|114613295\|ref\|XP_001152134.1\| PREDICTED: similar to hus1+-like isoform 1 [Pan troglodytes] gi\|194376608 - gi\|194376608\|dbj\|BAG57450.1\| unnamed protein product [Homo sapiens]	377.0	[0..22]	[281..1]

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Predicted Domain #1

Region A:
Residues: [1-281]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFRAKIVDL ACLNHFTRVS NMIAKLAKTC TLRISPEKLN FILCDKLASG GVSMWCELEQ  60
   61 ENFFSEFQME GVSEENNEIY LELTSENLSR ALKTAQNSRA LKIKLTNKHF PCLTVSVELQ 120
  121 VSSSSSSRIV VHDIPIKVLP RRLWKDLQEP SIPDCDVSIC LPALKMMKSV VEKMRNISNQ 180
  181 LVIEANLKGE LNLKIETELV CVTTHFKDLE NPLLPSDSVS QNRHPEDMAK VHIDIKKLLQ 240
  241 FLAGQQVTPT KAVCNIVNNR TVHFDLLLED VSLQYFIPAL S

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.47
Match:	1iz5A
Description:	Prolifirating cell nuclear antigen (PCNA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-directed DNA polymerase activity	4.54147976644866	bayes_pls_golite062009
DNA polymerase activity	4.49701701569573	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	3.19456659721176	bayes_pls_golite062009
nucleotidyltransferase activity	2.9050188778268	bayes_pls_golite062009
DNA polymerase processivity factor activity	2.66337934286498	bayes_pls_golite062009
transferase activity	2.40946730896889	bayes_pls_golite062009
DNA binding	2.04318251261279	bayes_pls_golite062009
nucleic acid binding	2.01144876655621	bayes_pls_golite062009
binding	1.89545142352738	bayes_pls_golite062009
protein binding	1.506175977955	bayes_pls_golite062009
structure-specific DNA binding	0.747485459405256	bayes_pls_golite062009
catalytic activity	0.474398499157949	bayes_pls_golite062009
double-stranded DNA binding	0.397447452409526	bayes_pls_golite062009
mismatched DNA binding	0.360278840045828	bayes_pls_golite062009
DNA insertion or deletion binding	0.130265364927567	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: