YRC Public Data Repository - Protein Structure Prediction

Protein:	COX41_MOUSE
Organism:	Mus musculus
Length:	169 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COX41_MOUSE.

Description	E-value	Query Range	Subject Range
COX41_RAT - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Rattus norvegicus GN=Cox4i1 PE=1 SV=1	282.0	[0..1]	[169..1]
gi\|57087091 - gi\|57087091\|ref\|XP_536759.1\| PREDICTED: similar to Cytochrome c oxidase subunit IV isoform 1, mitoch...	281.0	[0..1]	[169..1]
gi\|123992973, gi... - gi\|61357719\|gb\|AAX41434.1\| cytochrome c oxidase subunit IV isoform 1 [synthetic construct], gi\|12399... COX4I1 - cytochrome c oxidase subunit IV isoform 1 gi\|114663969, gi... - gi\|114663971\|ref\|XP_511235.2\| PREDICTED: similar to Cytochrome c oxidase subunit 4 isoform 1, mitoch...	280.0	[0..1]	[169..1]
COX41_BOVIN - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Bos taurus GN=COX4I1 PE=1 SV=1	279.0	[0..1]	[169..1]
gi\|109129422, gi... - gi\|109129422\|ref\|XP_001083946.1\| PREDICTED: similar to Cytochrome c oxidase subunit 4 isoform 1, mit...	279.0	[0..1]	[169..1]
COX41_RABIT - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Oryctolagus cuniculus GN=COX4I1 PE=2 SV=1	278.0	[0..1]	[169..1]
gi\|1372988, gi\|1... - gi\|1372989\|gb\|AAB02140.1\| cytochrome c oxidase subunit IV, gi\|1372988\|gb\|AAB02139.1\| cytochrome c ox...	277.0	[0..1]	[169..1]
gi\|197098966 - gi\|197098966\|ref\|NP_001126477.1\| cytochrome c oxidase subunit IV isoform 1 [Pongo abelii] gi\|55731628 - gi\|55731628\|emb\|CAH92520.1\| hypothetical protein [Pongo abelii]	273.0	[0..1]	[169..1]

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Predicted Domain #1

Region A:
Residues: [1-169]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLASRALSLI GKRAISTSVC LRAHGSVVKS EDYAFPTYAD RRDYPLPDVA HVTMLSASQK  60
   61 ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNRGTNEW KTVVGMAMFF IGFTALVLIW 120
  121 EKSYVYGPIP HTFDRDWVAM QTKRMLDMKA NPIQGFSAKW DYDKNEWKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.69897
Match:	1occD
Description:	Mitochondrial cytochrome c oxidase subunit IV
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytochrome-c oxidase activity	10.0916259129086	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors	10.0916259129086	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	10.0916259129086	bayes_pls_golite062009
heme-copper terminal oxidase activity	9.77879779666861	bayes_pls_golite062009
oxidoreductase activity	5.40847023303734	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.04528830783199	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.89821485878075	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.26027416842726	bayes_pls_golite062009
cation transmembrane transporter activity	3.01385615587113	bayes_pls_golite062009
ion transmembrane transporter activity	2.80992056655414	bayes_pls_golite062009
binding	1.36367731994148	bayes_pls_golite062009
catalytic activity	0.600497727931764	bayes_pls_golite062009
protein binding	0.289427729451854	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: