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View Structure Prediction Details

Protein: FBpp0300846
Organism: Drosophila melanogaster
Length: 1939 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0300846.

Description E-value Query
Range		 Subject
Range
gi|28261017 - gi|28261017|gb|AAO32792.1| scribbled [Drosophila melanogaster]
 1126.0 [0..95] [1939..2]

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Predicted Domain #1
Region A:
Residues: [1-708] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKCIPIFKG CNRQVEFVDK RHCSLPQVPE EILRYSRTLE ELFLDANHIR DLPKNFFRLH  60
   61 RLRKLGLSDN EIGRLPPDIQ NFENLVELDV SRNDIPDIPD DIKHLQSLQV ADFSSNPIPK 120
  121 LPSGFSQLKN LTVLGLNDMS LTTLPADFGS LTQLESLELR ENLLKHLPET ISQLTKLKRL 180
  181 DLGDNEIEDL PPYLGYLPGL HELWLDHNQL QRLPPELGLL TKLTYLDVSE NRLEELPNEI 240
  241 SGLVSLTDLD LAQNLLEALP DGIAKLSRLT ILKLDQNRLQ RLNDTLGNCE NMQELILTEN 300
  301 FLSELPASIG QMTKLNNLNV DRNALEYLPL EIGQCANLGV LSLRDNKLKK LPPELGNCTV 360
  361 LHVLDVSGNQ LLYLPYSLVN LQLKAVWLSE NQSQPLLTFQ PDTDAETGEQ VLSCYLLPQQ 420
  421 EYQPITPARD LESDSEPFEE REPSRTVVKF SEEATQEKET PFVRQNTPHP KDLKAKAQKL 480
  481 KVERSRNEEH ANLVTLPEEN GTKLAETPTE TRTIANNHQQ QPHPVQQPIV GVNSKQPVVV 540
  541 GVVTPTTTTV APTGVQGGSE GASSTANNVK AATAAVVAEL AATVGGSDEV QDDDEQEDEF 600
  601 ESDRRVGFQV EGEDDDFYKR PPKLHRRDTP HHLKNKRVQH LTDKQASEIL ANALASQERN 660
  661 DTTPQHSLSG KVTSPIEEEE QLEVEQEQQQ QQQQHPFDSS LSPISAGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 2a0zA
Description: The molecular structure of toll-like receptor 3 ligand binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [709-814] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAEASTDPAN QAMFNVKIKV KEGNNTLPRN GQRSNGNFSY SGAGSGRNSP AMSSLRSSLA  60
   61 SSNRSPSGSL QRKGKRVRIV TSYDPIDRDY ERQRQHYDNL DGVTEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [815-908] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLEQYEIHIE RTAAGLGLSI AGGKGSTPFK GDDDGIFISR VTEAGPADLA GLKVGDKVIK  60
   61 VNGIVVVDAD HYQAVQVLKA CGAVLVLVVQ REVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.045757
Match: 2g2lA
Description: No description for 2g2lA was found.

Predicted Domain #4
Region A:
Residues: [909-1010] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLIGHPVFSE DGSVSQISVE TRPLVADAPP AASISHERYI PAPIEIVPQQ QHLQQQQQQP  60
   61 IQQVAPTHSY SGNVFATPTA AQTVQPAVSA APNGLLLNGR EA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1011-1111] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLSYIQLHTT LIRDQIGQGL GFSIAGGKGS PPFKDDCDGI FISRITEGGL AYRDGKIMVG  60
   61 DRVMAINGND MTEAHHDAAV ACLTEPQRFV RLVLQREYRG P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.154902
Match: 1x5qA
Description: Solution structure of the first PDZ domain of scribble homolog protein (hScrib)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.566291652083235 bayes_pls_golite062009
protein binding 0.52823753548825 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1112-1230] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEPPTSPRSP AVLNSLSPSG YLANRPANFS RSVVEVEQPY KYNTLATTTP TPKPTVPASI  60
   61 SNNNNTLPSS KTNGFATAAA ATIDSSTGQP VPAPRRTNSV PMGDGDIGAG STTSGDSGE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1231-1320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQPSSLRPLT SDDFQAMIPA HFLSGGSQHQ VHVARPNEVG VSAVTVNVNK PQPDLPMFPA  60
   61 APTELGRVTE TITKSTFTET VMTRITDNQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1p1dA
Description: Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.566291652083235 bayes_pls_golite062009
protein binding 0.52823753548825 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1321-1421] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEPLISEVVL PKNQGSLGFS IIGGTDHSCV PFGTREPGIF ISHIVPGGIA SKCGKLRMGD  60
   61 RILKVNEADV SKATHQDAVL ELLKPGDEIK LTIQHDPLPP G

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.78
Match: 1q7xA
Description: Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.441071632281575 bayes_pls_golite062009
protein binding 0.340478308461139 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1422-1525] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQEVLLSKAE GERLGMHIKG GLNGQRGNPA DPSDEGVFVS KINSVGAARR DGRLKVGMRL  60
   61 LEVNGHSLLG ASHQDAVNVL RNAGNEIQLV VCKGYDKSNL IHSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1ujuA
Description: Solution structure of the fourth PDZ domain of human scribble (KIAA0147 protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.566291652083235 bayes_pls_golite062009
protein binding 0.52823753548825 bayes_pls_golite062009

Predicted Domain #10
Region A:
Residues: [1526-1639] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQAGGMSTGF NSSASCSGGS RQGSRASETG SELSQSQSVS SLDHEEDERL RQDFDVFASQ  60
   61 KPDAQQPTGP SVLAAAAAMV HGASSPTPPA ATSNITPLPT AAAVASADLT APDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1640-1825] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PATQTVALIH AEQQAHQQQQ QTQLAPLGQE KSTQEKVLEI VRAADAFTTV PPKSPSEHHE  60
   61 QDKIQKTTTV VISKHTLDTN PTTPTTPAAP LSIAGAESAN SAGAPSPAVP ASTPGSAPVL 120
  121 PAVAVQTQTQ TTSTEKDEEE ESQLQSTPAS RDGAEEQQEE VRAKPTPTKV PKSVSDKKRF 180
  181 FESAME

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1826-1939] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQHKPTQKTD KVFSFLSKDE VEKLRQEEER KIATLRRDKN SRLLDAANDN IDKDAAQQRT  60
   61 KSNSNSSSGD DNDDSDQEEG IARGDSVDNA ALGHFDDAED MRNPLDEIEA VFRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle