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View Structure Prediction Details

Protein: Dscam-PAK
Organism: Drosophila melanogaster
Length: 2032 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PAK.

Description E-value Query
Range
Subject
Range
Dscam-PAO - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1514.0 [0..3] [2032..3]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YEAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.0
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [145-810]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMTEYVIRGN AAVLKCSIPS FVADFVRVES WIDDEGNVLS FSDNYDGKYL VLPSGELHIR  60
   61 EVGPEDGYKS YQCRTKHRLT GETRLSATKG RLVITEPVGS VAPKVDVKDR ITWLDKPMGQ 120
  121 ALSLLCPAQS YPMPVYRWYK FIEGTTRKQA VVLNDRVKQV SGTLIIKDAV VEDSGKYLCV 180
  181 VNNSVGGESV ETVLTVTAPL SAKIDPPTQT VDFGRPAVFT CQYTGNPIKT VSWMKDGKAI 240
  241 GHSEPVLRIE SVKKEDKGMY QCFVRNDQES AEASAELKLG GRFDPPVIRQ AFQEETMEPG 300
  301 PSVFLKCVAG GNPTPEISWE LDGKKIANND RYQVGQYVTV NGDVVSYLNI TSVHANDGGL 360
  361 YKCIAKSKVG VAEHSAKLNV YGLPYIRQME KKAIVAGETL IVTCPVAGYP IDSIVWERDN 420
  421 RALPINRKQK VFPNGTLIIE NVERNSDQAT YTCVAKNQEG YSARGSLEVQ VMVPPSIAPF 480
  481 SFGDDPVNTG ENAGVQCMVQ KGDVPITIKW TLNSRPIING EEGITILKLS PKTSVLNIAA 540
  541 VEQDHRGVFK CIAENKAGSS FTTSELKVNV PPRWILEPTD KAFAQGSDAK VECKADGFPK 600
  601 PQVTWKKAVG DTPGEYKDLK KSDNIRVEEG TLHVDNIQKT NEGYYLCEAI NGIGSGLSAV 660
  661 IMISVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [811-997]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APPEFTEKLR NQTARRGEPA VLQCEAKGEK PIGILWNMNN MRLDPKNDNR YTIREEILST  60
   61 GVMSSLSIKR TERSDSALFT CVATNAFGSD DASINMIVQE VPEMPYALKV LDKSGRSVQL 120
  121 SWAQPYDGNS PLDRYIIEFK RSRASWSEID RVIVPGHTTE AQVQKLSPAT TYNIRIVAEN 180
  181 AIGTSQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #4
Region A:
Residues: [998-1114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEAVTIITAE EAPSGKPQNI KVEPVNQTTM RVTWKPPPRT EWNGEILGYY VGYKLSNTNS  60
   61 SYVFETINFI TEEGKEHNLE LQNLRVYTQY SVVIQAFNKI GAGPLSEEEK QFTAEGT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.69897
Match: 1cfbA
Description: CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1115-1702]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQPPSDTAC TTLTSQTIRV GWVSPPLESA NGVIKTYKVV YAPSDEWYDE TKRHYKKTAS  60
   61 SDTVLHGLKK YTNYTMQVLA TTAGGDGVRS VPIHCQTEPD VPEAPTDVKA LVMGNAAILV 120
  121 SWRPPAQPNG IITQYTVYSK AEGAETETKT QKVPHYQMSF EATELEKNKP YEFWVTASTT 180
  181 IGEGQQSKSI VAMPSDQVPA KIASFDDTFT ATFKEDAKMP CLAVGAPQPE ITWKIKGVEF 240
  241 SANDRMRVLP DGSLLIKSVN RQDAGDYSCH AENSIAKDSI THKLIVLAPP QSPHVTLSAT 300
  301 TTDALTVKLK PHEGDTAPLH GYTLHYKPEF GEWETSEVSV DSQKHNIEGL LCGSRYQVYA 360
  361 TGFNNIGAGE ASDILNTRTK GQKPKLPEKP RFIEVSSNSV SLHFKAWKDG GCPMSHFVVE 420
  421 SKKRDQIEWN QISNNVKPDN NYVVLDLEPA TWYNLRITAH NSAGFTVAEY DFATLTVTGG 480
  481 TIAPLDDGSG HGNVHTRIRL PAWMPEWLDL NFMVPLIATV VVVAVGICVV CVALSRRRAD 540
  541 DMRGGQKDVY YDVVYNQTMG PGATLDKRRP DLRDELGYIA PPNRKLPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #6
Region A:
Residues: [1703-1839]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGSNYNTCD RIKRGRGGLR SNHSTWDPRR NPNLYEELKA PPVPMHGNHY GHAHGNAECH  60
   61 YRHPGMEDEI CPYATFHLLG FREEMDPTKA MNFQTFPHQN GHAGPVPGHA GTMLPPGHPG 120
  121 HVHSRSGSQS MPRANRY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1840-2032]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRKNSQGGQS SIYTPAPEYD DPANCAEEDQ YRRYTRVNSQ GGSLYSGPGP EYDDPANCAP  60
   61 EEDQYGSQYG GPYGQPYDHY GSRGSMGRRS IGSARNPGNG SPEPPPPPPR NHDMSNSSFN 120
  121 DSKESNEISE AECDRDHGPR GNYGAVKRSP QPKDQRTTEE MRKLIERNET GPKQLQLQQA 180
  181 NGAGFTAYDT MAV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle