YRC Public Data Repository - Protein Structure Prediction

Protein:	FOLR2_MOUSE
Organism:	Mus musculus
Length:	251 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOLR2_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|4928857, gi\|4... - gi\|4928857\|gb\|AAD33740.1\|AF137373_1 secreted folate binding protein [Sus scrofa], gi\|47523188\|ref\|NP...	412.0	[0..1]	[251..1]
gi\|109462538, gi... - gi\|157820549\|ref\|NP_001099753.1\| folate receptor 2 (fetal) [Rattus norvegicus], gi\|149068711\|gb\|EDM1...	409.0	[0..1]	[250..1]
gi\|5823002 - gi\|5823002\|gb\|AAD53001.1\|AF061256_1 folate receptor alpha [Cricetulus griseus]	391.0	[0..14]	[249..19]
gi\|114639248 - gi\|114639248\|ref\|XP_001174682.1\| PREDICTED: similar to Folate receptor 2 (fetal) isoform 7 [Pan trog...	387.0	[0..1]	[230..18]
gi\|73988197 - gi\|73988197\|ref\|XP_534020.2\| PREDICTED: similar to Folate receptor beta precursor (FR-beta) (Folate ...	387.0	[0..1]	[251..9]
gi\|182422 - gi\|182422\|gb\|AAA74896.1\| folate-binding protein	384.0	[0..17]	[242..1]
gi\|60834983 - gi\|60834983\|gb\|AAX37119.1\| folate receptor 1 [synthetic construct]	384.0	[0..15]	[237..22]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWKQTPLLL LVYMVTTGSG RDRTDLLNVC MDAKHHKTKP GPEDKLHDQC SPWKKNACCS  60
   61 VNTSQELHKA DSRLYFNWDH CGKMEPACKS HFIQDSCLYE CSPNLGPWIQ QVDQSWRKER 120
  121 FLDVPLCKED CHQWWEACRT SFTCKRDWHK GWDWSSGINK CPNTAPCHTF EYYFPTPASL 180
  181 CEGLWSHSYK VSNYSRGSGR CIQMWFDSTQ GNPNEDVVKF YASFMTSGTV PHAAVLLVPS 240
  241 LAPVLSLWLP G

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.15
Match:	1ijyA
Description:	Frizzled 8 (FZ8)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	2.08776435219204	bayes_pls_golite062009
receptor activity	2.00965973106304	bayes_pls_golite062009
protein binding	1.4376087966006	bayes_pls_golite062009
binding	1.07458550397068	bayes_pls_golite062009
signal transducer activity	0.94079410434809	bayes_pls_golite062009
molecular transducer activity	0.94079410434809	bayes_pls_golite062009
Wnt receptor activity	0.807941216338025	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: