YRC Public Data Repository - Protein Structure Prediction

Protein:	RASAL2
Organism:	Homo sapiens
Length:	1139 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RASAL2.

Description	E-value	Query Range	Subject Range
gi\|25121936 - gi\|25121936\|ref\|NP_733793.1\| RAS protein activator like 2 isoform 2 [Homo sapiens]	0.0	[5..1139]	[135..1269]
gi\|109498883, gi... - gi\|109498883\|ref\|XP_001073199.1\| PREDICTED: similar to RAS protein activator like 2 isoform 2 [Rattu...	0.0	[5..1139]	[152..1286]
gi\|111308942, gi... - gi\|113199763\|ref\|NP_808312.2\| RAS protein activator like 2 [Mus musculus], gi\|111308942\|gb\|AAI20903....	0.0	[5..1139]	[134..1268]
gi\|114568112, gi... - gi\|114568114\|ref\|XP_001154236.1\| PREDICTED: RAS protein activator like 2 isoform 7 [Pan troglodytes]...	0.0	[5..1139]	[153..1287]
gi\|73960548 - gi\|73960548\|ref\|XP_850226.1\| PREDICTED: similar to Ras GTPase-activating protein nGAP (RAS protein a...	0.0	[1..1139]	[1..1139]

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Predicted Domain #1

Region A:
Residues: [1-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTPEVPAER SPRRRSISGT STSEKPNSMD TANTSPFKVP GFFSKRLKGS IKRTKSQSKL  60
   61 DRNTSFRLPS LRSTDDRSRG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [81-159]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPKLKESRSH ESLLSPCSTV ECLDLGRGEP VSVKPLHSSI LGQDFCFEVT YLSGSKCFSC  60
   61 NSASERDKWM ENLRRTVQP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.522879
Match:	1ki1B
Description:	GEF of intersectin
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [160-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKDNCRRAEN VLRLWIIEAK DLAPKKKYFC ELCLDDTLFA RTTSKTKADN IFWGEHFEFF  60
   61 SLPPLHSITV HIYKDVEKKK KKDKNNYVGL VNIPTASVTG RQFVEKWYPV STPTP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.522879
Match:	2enpA
Description:	No description for 2enpA was found.

Predicted Domain #4

Region A:
Residues: [275-371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKGKTGGPSI RIKSRFQTIT ILPMEQYKEF AEFVTSNYTM LCSVLEPVIS VRNKEELACA  60
   61 LVHILQSTGR AKDFLTDLVM SEVDRCGEHD VLIFREN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.69897
Match:	1werA
Description:	RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTPase regulator activity	2.93605169651831	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.90950506941724	bayes_pls_golite062009
GTPase activator activity	2.89158618018952	bayes_pls_golite062009
enzyme activator activity	2.65585309928131	bayes_pls_golite062009
enzyme regulator activity	2.60801221683922	bayes_pls_golite062009
small GTPase regulator activity	2.49898939104391	bayes_pls_golite062009
Ras GTPase activator activity	2.47392481225609	bayes_pls_golite062009
Rho GTPase activator activity	2.25477524109807	bayes_pls_golite062009
binding	1.36633307106754	bayes_pls_golite062009
Rac GTPase activator activity	1.03094355400281	bayes_pls_golite062009
protein binding	0.959391682784807	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [372-911]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIATKSIEEY LKLVGQQYLH DALGEFIKAL YESDENCEVD PSKCSSSELI DHQSNLKMCC  60
   61 ELAFCKIINS YCVFPRELKE VFASWKQQCL NRGKQDISER LISASLFLRF LCPAIMSPSL 120
  121 FNLMQEYPDD RTSRTLTLIA KVIQNLANFA KFGNKEEYMA FMNDFLEHEW GGMKRFLLEI 180
  181 SNPDTISNTP GFDGYIDLGR ELSVLHSLLW EVVSQLDKGE NSFLQATVAK LGPLPRVLAD 240
  241 ITKSLTNPTP IQQQLRRFTE HNSSPNVSGS LSSGLQKIFE DPTDSDLHKL KSPSQDNTDS 300
  301 YFRGKTLLLV QQASSQSMTY SEKDERESSL PNGRSVSLMD LQDTHAAQVE HASVMLDVPI 360
  361 RLTGSQLSIT QVASIKQLRE TQSTPQSAPQ VRRPLHPALN QPGGLQPLSF QNPVYHLNNP 420
  421 IPAMPKASID SSLENLSTAS SRSQSNSEDF KLSGPSNSSM EDFTKRSTQS EDFSRRHTVP 480
  481 DRHIPLALPR QNSTGQAQIR KVDQGGLGAR AKAPPSLPHS ASLRSTGSMS VVSAALVAEP 540
  541

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.221849
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [912-1139]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQNGSRSRQQ SSSSRESPVP KVRAIQRQQT QQVQSPVDSA TMSPVERTAA WVLNNGQYEE  60
   61 DVEETEQNLD EAKHAEKYEQ EITKLKERLR VSSRRLEEYE RRLLVQEQQM QKLLLEYKAR 120
  121 LEDSEERLRR QQEEKDSQMK SIISRLMAVE EELKKDHAEM QAVIDAKQKI IDAQEKRIVS 180
  181 LDSANTRLMS ALTQVKERYS MQVRNGISPT NPTKLSITEN GEFKNSSC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.154902
Match:	1c1gA
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: