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View Structure Prediction Details

Protein: gi|11641415, gi|...
Organism: Homo sapiens
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|11641415, gi|....

Description E-value Query
Range
Subject
Range
gi|114680703 - gi|114680703|ref|XP_001162213.1| PREDICTED: cell division cycle 25B isoform 4 [Pan troglodytes]
0.0 [1..601] [1..601]
gi|119630903, gi... - gi|4757950|ref|NP_004349.1| cell division cycle 25B isoform 2 [Homo sapiens], gi|180173|gb|AAA58416....
0.0 [1..601] [1..566]
gi|248473 - gi|248473|gb|AAB22026.1| Cdc25M2 [Mus sp.]
MPIP2_MOUSE - M-phase inducer phosphatase 2 OS=Mus musculus GN=Cdc25b PE=1 SV=1
0.0 [1..601] [1..576]
gi|30584239, gi|... - gi|60653191|gb|AAX29290.1| cell division cycle 25B [synthetic construct], gi|30584239|gb|AAP36368.1|...
0.0 [1..601] [1..580]
gi|7435156 - gi|7435156|pir||I66868 cdc25B - rat
MPIP2_RAT - M-phase inducer phosphatase 2 OS=Rattus norvegicus GN=Cdc25b PE=1 SV=1
0.0 [1..601] [1..574]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH  60
   61 DLAGLGSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD SPSPMDPHMA EQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.235 a.118.1 ARM repeat

Predicted Domain #2
Region A:
Residues: [114-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEQAIQAASR IIRNEQFAIR RFQSMPVRLL GHSPVLRNIT NSQAPDGRRK SEAGSGAASS  60
   61 SGEDKENVRF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.580 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.548 N/A N/A a.64.1 Saposin
View Download 0.402 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.385 N/A N/A a.60.12 DNA polymerase beta-like, second domain
View Download 0.338 N/A N/A a.5.2 UBA-like

Predicted Domain #3
Region A:
Residues: [184-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WKAGVGALRE EEGACWGGSL ACEDPPLPSW LQDGFVFKMP WKPTHPSSTH ALAEWASRRE  60
   61 AFAQRPSSAP DLMCLSPDRK MEVEELSPLA LGRFSLTPAE GDTEEDDGFV DILESDLKDD 120
  121 DAVPPGMESL ISAPLVKTLE KEEEKDLVMY SKCQRLFRSP SMPCSVIRPI LKRLERPQDR 180
  181 DTPVQNKRRR SVTPPEEQQE 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [384-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEEPKARVLR SKSLCHDEIE NLLDSDHREL IGDYSKAFLL QTVDGKHQDL KYISPETMVA  60
   61 LLTGKFSNIV DKFVIVDCRY PYEYEGGHIK TAVNLPLERD AESFLLKSPI APCSLDKRVI 120
  121 LIFHCEFSSE RGPRMCRFIR ERDRAVNDYP SLYYPEMYIL KGGYKEFFPQ HPNFCEPQDY 180
  181 RPMNHEAFKD ELKTFRLKTR SWAGERSRRE LCSRLQDQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1cwrA
Description: CDC25b
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.72957395505299 bayes_pls_golite062009
protein binding 1.56606332199727 bayes_pls_golite062009
transferase activity 1.33105059149882 bayes_pls_golite062009
WW domain binding 1.14539899569473 bayes_pls_golite062009
phosphatase activity 0.885629090118187 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.802155325212406 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.71357098492815 bayes_pls_golite062009
catalytic activity 0.687308230067573 bayes_pls_golite062009
protein tyrosine phosphatase activity 0.257287361342848 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle