YRC Public Data Repository - Protein Structure Prediction

Protein:	NUDT9
Organism:	Homo sapiens
Length:	350 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUDT9.

Description	E-value	Query Range	Subject Range
gi\|21309854 - gi\|21309854\|gb\|AAM46068.1\| NUDT10 [Homo sapiens]	0.0	[1..350]	[1..350]
gi\|61372006, gi\|... - gi\|61372006\|gb\|AAX43771.1\| nudix-type motif 9 [synthetic construct], gi\|30583845\|gb\|AAP36171.1\| Homo...	0.0	[1..350]	[1..350]
gi\|114595031, gi... - gi\|55622918\|ref\|XP_526628.1\| PREDICTED: nudix -type motif 9 isoform 4 [Pan troglodytes], gi\|11459503...	0.0	[1..350]	[1..350]
gi\|21706762 - gi\|21706762\|gb\|AAH33921.1\| Nudix (nucleoside diphosphate linked moiety X)-type motif 9 [Mus musculus...	0.0	[1..350]	[1..350]
NUDT9_RAT - ADP-ribose pyrophosphatase, mitochondrial OS=Rattus norvegicus GN=Nudt9 PE=2 SV=1 gi\|55741431 - ref\|NP_001006992.1\| nudix -type motif 9 [Rattus norvegicus]	0.0	[1..350]	[1..350]
gi\|76620319 - gi\|76620319\|ref\|XP_595761.2\| PREDICTED: similar to nudix -type motif 9 isoform a [Bos taurus]	0.0	[1..349]	[103..451]

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Predicted Domain #1

Region A:
Residues: [1-350]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGRLLGKAL AAVSLSLALA SVTIRSSRCR GIQAFRNSFS SSWFHLNTNV MSGSNGSKEN  60
   61 SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT AVSVLAGPRW ADPQISESNF 120
  121 SPKFNEKDGH VERKSKNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA ADPIITRWKR 180
  181 DSSGNKIMHP VSGKHILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ 240
  241 KTSAEKREIE EKLHKLFSQD HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGEIMDNLML 300
  301 EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	100.0
Match:	1q33A
Description:	Crystal structure of human ADP-ribose pyrophosphatase NUDT9
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	1.69462445173623	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.60137862064807	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.60031942580353	bayes_pls_golite062009
catalytic activity	1.49075808737475	bayes_pls_golite062009
ion transmembrane transporter activity	1.25618868050386	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.24835535003371	bayes_pls_golite062009
cation transmembrane transporter activity	1.23012516113675	bayes_pls_golite062009
hydrolase activity	1.08437985755037	bayes_pls_golite062009
pyrophosphatase activity	0.972834531999993	bayes_pls_golite062009
transporter activity	0.528705547125716	bayes_pls_golite062009
binding	0.51827348489117	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.399993372782406	bayes_pls_golite062009
transmembrane transporter activity	0.305035244933221	bayes_pls_golite062009
nucleoside-diphosphatase activity	0.123453631031085	bayes_pls_golite062009
nucleic acid binding	0.0715631252684563	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: