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View Structure Prediction Details

Protein: gi|40288288, gi|...
Organism: Homo sapiens
Length: 608 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|40288288, gi|....

Description E-value Query
Range
Subject
Range
gi|71795662, gi|... - gi|71795662|ref|NP_001025212.1| coactivator-associated arginine methyltransferase 1 isoform a [Rattu...
CARM1_MOUSE - Histone-arginine methyltransferase CARM1 OS=Mus musculus GN=Carm1 PE=1 SV=2
0.0 [26..608] [27..608]
CARM1_RAT - Histone-arginine methyltransferase CARM1 OS=Rattus norvegicus GN=Carm1 PE=1 SV=1
0.0 [26..608] [27..651]
CARM1 - coactivator-associated arginine methyltransferase 1
0.0 [25..608] [25..585]
CARM1_DANRE - Histone-arginine methyltransferase CARM1 OS=Danio rerio GN=carm1 PE=2 SV=1
0.0 [30..608] [4..588]
CARM1_XENLA - Histone-arginine methyltransferase CARM1 OS=Xenopus laevis GN=carm1 PE=2 SV=1
0.0 [30..608] [5..602]
gi|73986654 - gi|73986654|ref|XP_853774.1| PREDICTED: similar to coactivator-associated arginine methyltransferase...
0.0 [151..608] [4..461]
gi|47216268 - gi|47216268|emb|CAG05964.1| unnamed protein product [Tetraodon nigroviridis]
0.0 [30..608] [4..538]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAAAVGP GAGGAGSAVP GGAGPCATVS VFPGARLLTI GDANGEIQRH AEQQALRLEV  60
   61 RAGPDSAGIA LYSHEDVCVF KCSVSRETEC SRVGKQSFII TLGCNSVLIQ FATPNDFCSF 120
  121 YNILKTCRGH TLERS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 1wxwA
Description: Crystal structure of Tt1595, a putative SAM-dependent methyltransferase from Thermus thermophillus HB8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.36322489802895 bayes_pls_golite062009
nucleic acid binding 2.1776279023087 bayes_pls_golite062009
DNA binding 2.00644232993633 bayes_pls_golite062009
binding 1.75638932389306 bayes_pls_golite062009
transcription factor activity 1.30276669414152 bayes_pls_golite062009
protein binding 0.37678401200507 bayes_pls_golite062009
catalytic activity 0.147263815852997 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0250652037156978 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [136-530]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VFSERTEESS AVQYFQFYGY LSQQQNMMQD YVRTGTYQRA ILQNHTDFKD KIVLDVGCGS  60
   61 GILSFFAAQA GARKIYAVEA STMAQHAEVL VKSNNLTDRI VVIPGKVEEV SLPEQVDIII 120
  121 SEPMGYMLFN ERMLESYLHA KKYLKPSGNM FPTIGDVHLA PFTDEQLYME QFTKANFWYQ 180
  181 PSFHGVDLSA LRGAAVDEYF RQPVVDTFDI RILMAKSVKY TVNFLEAKEG DLHRIEIPFK 240
  241 FHMLHSGLVH GLAFWFDVAF IGSIMTVWLS TAPTEPLTHW YQVRCLFQSP LFAKAGDTLS 300
  301 GTCLLIANKR QSYDISIVAQ VDQTGSKSSN LLDLKNPFFR YTGTTPSPPP GSHYTSPSEN 360
  361 MWNTGSTYNL SSGMAVAGMP TAYDLSSVIA SGSSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.09691
Match: 2v74B
Description: No description for 2v74B was found.

Predicted Domain #3
Region A:
Residues: [531-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHNNLIPLAN TGIVNHTHSR MGSIMSTGIV QGSSGAQGSG GGSTSAHYAV NSQFTMGGPA  60
   61 ISMASPMSIP TNTMHYGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle