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View Structure Prediction Details

Protein: PGRMC1
Organism: Homo sapiens
Length: 195 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGRMC1.

Description E-value Query
Range		 Subject
Range
PGRC1_PONPY - Membrane-associated progesterone receptor component 1 - Pongo pygmaeus (Orangutan)
PGRC1_PONAB - Membrane-associated progesterone receptor component 1 OS=Pongo abelii GN=PGRMC1 PE=2 SV=3
 3.0E-48 [1..195] [1..195]
PGRC1_MOUSE - Membrane-associated progesterone receptor component 1 OS=Mus musculus GN=Pgrmc1 PE=1 SV=4
 5.0E-48 [1..195] [1..195]
gi|7513461 - pir||JC5260 progesterone membrane binding protein - pig
PGRC1_PIG - Membrane-associated progesterone receptor component 1 OS=Sus scrofa GN=PGRMC1 PE=1 SV=3
 3.0E-47 [1..195] [1..194]
PGRC1_BOVIN - Membrane-associated progesterone receptor component 1 OS=Bos taurus GN=PGRMC1 PE=2 SV=3
 5.0E-47 [1..195] [1..194]
gi|57112339 - gi|57112339|ref|XP_538151.1| PREDICTED: similar to progesterone receptor membrane component [Canis f...
 6.0E-47 [1..195] [1..195]
gi|109132048 - gi|109132048|ref|XP_001100639.1| PREDICTED: similar to progesterone receptor membrane component 1 [M...
 3.0E-46 [1..195] [1..204]

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Predicted Domain #1
Region A:
Residues: [1-195] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAEDVVATG ADPSDLESGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ PAASGDSDDD  60
   61 EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV TKGRKFYGPE GPYGVFAGRD 120
  121 ASRGLATFCL DKEALKDEYD DLSDLTAAQQ ETLSDWESQF TFKYHHVGKL LKEGEEPTVY 180
  181 SDEEEPKDES ARKND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.39794
Match: 1j03A
Description: Solution structure of a putative steroid-binding protein from Arabidopsis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.76718756313666 bayes_pls_golite062009
transporter activity 0.920087041947819 bayes_pls_golite062009
signal transducer activity 0.76215529135227 bayes_pls_golite062009
molecular transducer activity 0.76215529135227 bayes_pls_golite062009
transmembrane transporter activity 0.739503099682459 bayes_pls_golite062009
substrate-specific transporter activity 0.535501995010142 bayes_pls_golite062009
receptor activity 0.460667473683829 bayes_pls_golite062009
protein binding 0.368622185753917 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.314610777889032 bayes_pls_golite062009
steroid binding 0.177535173083536 bayes_pls_golite062009
ion transmembrane transporter activity 0.0578908750434612 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle