YRC Public Data Repository - Protein Structure Prediction

Protein:	CALCA
Organism:	Homo sapiens
Length:	128 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CALCA.

Description	E-value	Query Range	Subject Range
gi\|109107198 - gi\|109107198\|ref\|XP_001092199.1\| PREDICTED: calcitonin-related polypeptide, beta [Macaca mulatta]	213.0	[0..1]	[128..1]
CALCB - calcitonin-related polypeptide beta	208.0	[0..1]	[128..1]
CALCA_RAT - Calcitonin gene-related peptide 1 OS=Rattus norvegicus GN=Calca PE=2 SV=1	207.0	[0..1]	[128..1]
gi\|114636335 - gi\|114636335\|ref\|XP_529390.2\| PREDICTED: similar to Calcitonin gene-related peptide 2 precursor (Cal...	206.0	[0..1]	[128..12]
gi\|116062123, gi... - gi\|157278525\|ref\|NP_001098364.1\| calcitonin gene-related peptide 2 [Oryzias latipes], gi\|116062123\|d...	201.0	[0..1]	[127..1]
CALCA_CHICK - Calcitonin gene-related peptide OS=Gallus gallus GN=CALCA PE=2 SV=2	201.0	[0..1]	[127..1]
gi\|19772948 - gi\|19772948\|emb\|CAC81277.1\| calcitonin gene related peptide [Takifugu rubripes]	198.0	[0..1]	[127..1]
CRSP3_PIG - Calcitonin receptor-stimulating peptide 3 OS=Sus scrofa GN=CRSP3 PE=2 SV=1	197.0	[0..1]	[128..1]
CALCA_HORSE - Calcitonin gene-related peptide 1 OS=Equus caballus GN=CALCA PE=2 SV=1	192.0	[0..1]	[128..1]
CRSP2_CANLF - Calcitonin receptor-stimulating peptide 2 OS=Canis lupus familiaris GN=CRSP2 PE=2 SV=1	191.0	[0..1]	[128..1]

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Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ  60
   61 MKASELEQEQ EREGSRIIAQ KRACDTATCV THRLAGLLSR SGGVVKNNFV PTNVGSKAFG 120
  121 RRRRDLQA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.430	0.801	hormone activity	a.26.1	4-helical cytokines
View	Download	0.471	0.801	hormone activity	a.47.2	t-snare proteins
View	Download	0.385	0.801	hormone activity	a.7.1	Spectrin repeat
View	Download	0.334	0.801	hormone activity	c.84.1	Phosphoglucomutase, first 3 domains
View	Download	0.321	0.801	hormone activity	a.26.1	4-helical cytokines

Predicted functions:

Term	Confidence	Notes
binding	2.2912619716107	bayes_pls_golite062009
protein binding	1.9593327660138	bayes_pls_golite062009
ion transmembrane transporter activity	1.19752781612021	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.06747829758878	bayes_pls_golite062009
ion channel inhibitor activity	0.728958862998098	bayes_pls_golite062009
channel inhibitor activity	0.728958862998098	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: