YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|12697967
Organism:	Homo sapiens
Length:	1090 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|12697967.

Description	E-value	Query Range	Subject Range
gi\|57999471 - gi\|57999471\|emb\|CAI45944.1\| hypothetical protein [Homo sapiens]	0.0	[1..1090]	[406..1494]
gi\|114625365, gi... - gi\|114625365\|ref\|XP_001138539.1\| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes], gi\|114...	0.0	[1..1090]	[406..1494]
gi\|109112036, gi... - gi\|109112038\|ref\|XP_001083813.1\| PREDICTED: similar to zinc finger, CCHC domain containing 6 isoform...	0.0	[1..1090]	[406..1490]
gi\|73946401 - gi\|73946401\|ref\|XP_533505.2\| PREDICTED: similar to zinc finger, CCHC domain containing 6 isoform 1 [...	0.0	[1..1090]	[406..1495]
ZCHC6_MOUSE - Zinc finger CCHC domain-containing protein 6 OS=Mus musculus GN=Zcchc6 PE=2 SV=2	0.0	[1..1090]	[406..1491]

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Predicted Domain #1

Region A:
Residues: [1-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCKVSAGNEN ACLTTKHLTA LGKLEPKLVP LVIAFRYWAK LCSIDRPEEG GLPPYVFALM  60
   61 AIFFLQQRKE PLLPVYLGSW IEGFSLSKLG NFNLQDIEKD VVIWEHTDSA AGDTGITKEE 120
  121 APRETPIKRG QVSLILDVKH QPSVPVGQLW VELLRFYALE FNLADLVISI RVKELVSREL 180
  181 KDWPKKRIAI EDPYSVKRNV ARTLNSQPVF EYILHCLRTT YKYFALPHKI TKSSLLKPLN 240
  241 AITCI

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.26
Match:	2b4vA
Description:	Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [246-333]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEHSKEVINH HPDVQTKDDK LKNSVLAQGP GATSSAANTC KVQPLTLKET AESFGSPPKE  60
   61 EMGNEHISVH PENSDCIQAD VNSDDYKG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [334-533]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKVYHPETGR KNEKEKVGRK GKHLLTVDQK RGEHVVCGST RNNESESTLD LEGFQNPTAK  60
   61 ECEGLATLDN KADLDGESTE GTEELEDSLN HFTHSVQGQT SEMIPSDEEE EDDEEEEEEE 120
  121 EPRLTINQRE DEDGMANEDE LDNTYTGSGD EDALSEEDDE LGEAAKYEDV KECGKHVERA 180
  181 LLVELNKISL KEENVCEEKN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [534-929]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPVDQSDFFY EFSKLIFTKG KSPTVVCSLC KREGHLKKDC PEDFKRIQLE PLPPLTPKFL  60
   61 NILDQVCIQC YKDFSPTIIE DQAREHIRQN LESFIRQDFP GTKLSLFGSS KNGFGFKQSD 120
  121 LDVCMTINGL ETAEGLDCVR TIEELARVLR KHSGLRNILP ITTAKVPIVK FFHLRSGLEV 180
  181 DISLYNTLAL HNTRLLSAYS AIDPRVKYLC YTMKVFTKMC DIGDASRGSL SSYAYTLMVL 240
  241 YFLQQRNPPV IPVLQEIYKG EKKPEIFVDG WNIYFFDQID ELPTYWSECG KNTESVGQLW 300
  301 LGLLRFYTEE FDFKEHVISI RRKSLLTTFK KQWTSKYIVI EDPFDLNHNL GAGLSRKMTN 360
  361 FIMKAFINGR RVFGIPVKGF PKDYPSKMEY FFDPDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.522879
Match:	1f5aA
Description:	Poly(A) polymerase, middle domain; Poly(A) polymerase N-terminal, catalytic domain; Poly(A) polymerase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleotidyltransferase activity	3.12632133477736	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.03741071977036	bayes_pls_golite062009
nucleic acid binding	1.35958790110182	bayes_pls_golite062009
RNA binding	1.26469116227089	bayes_pls_golite062009
transferase activity	1.1355378442847	bayes_pls_golite062009
DNA polymerase activity	0.920730104361505	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.913497340211638	bayes_pls_golite062009
binding	0.841038039546473	bayes_pls_golite062009
DNA binding	0.782730432596522	bayes_pls_golite062009
catalytic activity	0.75232920999699	bayes_pls_golite062009
polynucleotide adenylyltransferase activity	0.747086661208511	bayes_pls_golite062009
protein binding	0.117945573723438	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [930-1090]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEGELAPND RCCRICGKIG HFMKDCPMRR KVRRRRDQED ALNQRYPENK EKRSKEDKEI  60
   61 HNKYTEREVS TKEDKPIQCT PQKAKPMRAA ADLGREKILR PPVEKWKRQD DKDLREKRCF 120
  121 ICGREGHIKK ECPQFKGSSG SLSSKYMTQG KASAKRTQQE S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: