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View Structure Prediction Details

Protein: NONO
Organism: Homo sapiens
Length: 471 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NONO.

Description E-value Query
Range
Subject
Range
gi|76689263 - gi|76689263|ref|XP_880772.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
7.0E-71 [12..460] [32..482]
gi|73976797 - gi|73976797|ref|XP_857696.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
6.0E-70 [12..460] [32..482]
gi|41388837 - gi|41388837|gb|AAH65540.1| PABPC4 protein [Homo sapiens]
9.0E-68 [12..465] [32..487]

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Predicted Domain #1
Region A:
Residues: [1-154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSNKTFNLE KQNHTPRKHH QHHHQQQHHQ QQQQQPPPPP IPANGQQASS QNEGLTIDLK  60
   61 NFRKPGEKTF TQRSRLFVGN LPPDITEEEM RKLFEKYGKA GEVFIHKDKG FGFIRLETRT 120
  121 LAEIAKVELD NMPLRGKQLR VRFACHSASL TVRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 2cpjA
Description: Solution structure of the N-terminal RNA recognition motif of NonO
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [155-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPQYVSNELL EEAFSVFGQV ERAVVIVDDR GRPSGKGIVE FSGKPAARKA LDRCSEGSFL  60
   61 LTTFPRPVTV EPMDQLDDEE GLPEKLVIKN QQFHKEREQP PRFAQPGSFE YEYAMRWKAL 120
  121 IEMEKQQQDQ VDRNIKEARE KLEMEMEAAR HEHQVMLMRQ DLMRRQEELR RMEELHNQEV 180
  181 QK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1qm9A
Description: Polypyrimidine tract-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
3.6767428476083 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
poly-pyrimidine tract binding 1.54272391619365 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
snRNA binding 0.90828362378369 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
protein binding 0.42571879933058 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [337-471]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKQLELRQEE ERRRREEEMR RQQEEMMRRQ QEGFKGTFPD AREQEIRMGQ MAMGGAMGIN  60
   61 NRGAMPPAPV PAGTPAPPGP ATMMPDGTLG LTPPTTERFG QAATMEGIGA IGGTPPAFNR 120
  121 AAPGAEFAPN KRRRY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle