YRC Public Data Repository - Protein Structure Prediction

Protein:	GIYD2, GIYD1
Organism:	Homo sapiens
Length:	275 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GIYD2, GIYD1.

Description	E-value	Query Range	Subject Range
gi\|109128179 - gi\|109128179\|ref\|XP_001109511.1\| PREDICTED: similar to GIY-YIG domain containing 2 isoform 1 isoform...	0.0	[1..275]	[1..275]
SLX1_RAT - Structure-specific endonuclease subunit SLX1 OS=Rattus norvegicus GN=Slx1b PE=2 SV=1	4.0E-99	[5..275]	[2..271]
SLX1_MOUSE - Structure-specific endonuclease subunit SLX1 OS=Mus musculus GN=Slx1b PE=2 SV=1	5.0E-99	[6..275]	[3..270]
gi\|73958514 - gi\|73958514\|ref\|XP_849594.1\| PREDICTED: similar to GIY-YIG domain containing 2 isoform 1 isoform 1 [...	4.0E-89	[1..275]	[1..272]
gi\|10440128 - gi\|10440128\|dbj\|BAB15654.1\| unnamed protein product [Homo sapiens]	8.0E-88	[1..241]	[1..241]
SLX1_BOVIN - Structure-specific endonuclease subunit SLX1 OS=Bos taurus GN=SLX1A PE=2 SV=1	1.0E-84	[10..275]	[3..267]
gi\|28381101, gi\|... - gi\|28571506\|ref\|NP_649484.2\| CG18271 [Drosophila melanogaster], gi\|28381101\|gb\|AAF52110.2\| CG18271 [...	6.0E-73	[8..266]	[28..287]
SLX1_SCHPO - Structure-specific endonuclease subunit slx1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ... slx1 - structure-specific endonuclease catalytic subunit	1.0E-70	[12..274]	[5..266]
gi\|125776368, gi... - gi\|54638997\|gb\|EAL28399.1\| GA14867-PA [Drosophila pseudoobscura], gi\|125776368\|ref\|XP_001359254.1\| G...	1.0E-68	[3..271]	[129..398]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPAGVAARP GRFFGVYLLY CLNPRYRGRV YVGFTVNTAR RVQQHNGGRK KGGAWRTSGR  60
   61 GPWEMVLVVH GFPSSVAALR FEWAWQHPHA SRRLAHVGPR LRGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.69897
Match:	1zg2A
Description:	Solution NMR structure of the UPF0213 protein BH0048 from Bacillus halodurans. Northeast Structural Genomics target BhR2.
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [105-275]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAFAFHLRVL AHMLRAPPWA RLPLTLRWVR PDLRQDLCLP PPPHVPLAFG PPPPQAPAPR  60
   61 RRAGPFDDAE PEPDQGDPGA CCSLCAQTIQ DEEGPLCCPH PGCLLRAHVI CLAEEFLQEE 120
  121 PGQLLPLEGQ CPCCEKSLLW GDLIWLCQMD TEKEVEDSEL EEAHWTDLLE T

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.69
Match:	1u6gB
Description:	Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.0159092335062434	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: