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View Structure Prediction Details

Protein: MSI2
Organism: Homo sapiens
Length: 328 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSI2.

Description E-value Query
Range
Subject
Range
gi|85057100, gi|... - gi|85057100|gb|AAI11810.1| Msi2h protein [Mus musculus], gi|58865071|emb|CAI52493.1| Musashi homolog...
5.0E-53 [1..328] [1..328]
gi|114669596 - gi|114669596|ref|XP_001162046.1| PREDICTED: similar to RNA-binding protein Musashi2-S [Pan troglodyt...
5.0E-52 [18..328] [14..324]
gi|73966528 - gi|73966528|ref|XP_532379.2| PREDICTED: similar to musashi 2 isoform a isoform 1 [Canis familiaris]
3.0E-51 [18..328] [14..324]
gi|109491620 - gi|109491620|ref|XP_001081205.1| PREDICTED: similar to Musashi homolog 2 [Rattus norvegicus]
1.0E-49 [29..328] [191..508]
gi|60688517, gi|... - gi|61806598|ref|NP_001013534.1| musashi homolog 1 [Danio rerio], gi|60688517|gb|AAH90916.1| Musashi ...
1.0E-49 [1..328] [1..330]
gi|54647597 - gi|54647597|gb|AAH84959.1| Msi1h protein [Xenopus laevis]
3.0E-46 [3..328] [2..321]
gi|56970642, gi|... - gi|58332792|ref|NP_001011470.1| musashi homolog 1 [Xenopus (Silurana) tropicalis], gi|56970642|gb|AA...
gi|52221204, gi|... - gi|52221204|gb|AAH82667.1| LOC397764 protein [Xenopus laevis], gi|214632|gb|AAA49920.1| pot. RNA-bin...
8.0E-46 [3..328] [2..340]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEANGSQGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC MVMRDPTTKR  60
   61 SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR AQPKMVTRTK KIFVGGLSAN 120
  121 TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH RGFGFVTFEN EDVVEKVCEI HFHEINNKMV 180
  181 ECKKAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.045757
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
poly(U) RNA binding 4.76054718156645 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
protein binding 1.14508556628804 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [187-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKEVMFPPGT RGRARGLPYT MDAFMLGMGM LGYPNFVATY GRGYPGFAPS YGYQFPGFPA  60
   61 AAYGPVAAAA VAAARGSGSN PARPGGFPGA NSPGPVADLY GPASQDSGVG NYISAASPQP 120
  121 GSGFGHGIAG PLIATAFTNG YH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle