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View Structure Prediction Details

Protein: IL22
Organism: Homo sapiens
Length: 179 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL22.

Description E-value Query
Range
Subject
Range
gi|109480593 - gi|109480593|ref|XP_576228.2| PREDICTED: similar to Interleukin-22 precursor (IL-22) (IL-10-related ...
2.0E-93 [1..179] [40..218]
gi|109097710 - gi|109097710|ref|XP_001117159.1| PREDICTED: similar to interleukin 22 [Macaca mulatta]
2.0E-92 [1..179] [1..179]
IL22_MOUSE - Interleukin-22 OS=Mus musculus GN=Il22 PE=2 SV=1
2.0E-91 [1..179] [1..179]
gi|57092623 - gi|57092623|ref|XP_538274.1| PREDICTED: similar to interleukin 22 [Canis familiaris]
2.0E-90 [1..179] [1..179]
gi|45709434 - gi|45709434|gb|AAH67509.1| Interleukin 22 [Homo sapiens]
3.0E-87 [1..179] [1..179]

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Predicted Domain #1
Region A:
Residues: [1-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP YITNRTFMLA  60
   61 KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP 120
  121 FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.0
Match: 1m4rA
Description: Interleukin-22 (IL-22)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 4.48255796229335 bayes_pls_golite062009
growth factor activity 3.72884804690203 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
hormone activity 2.25587306265428 bayes_pls_golite062009
interleukin-6 receptor binding 1.83023187600069 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.60208922619429 bayes_pls_golite062009
growth hormone activity 1.56248526441167 bayes_pls_golite062009
interleukin-27 binding 0.90622262066644 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-10 receptor binding 0.236156614421821 bayes_pls_golite062009
erythropoietin receptor binding 0.0586722042942722 bayes_pls_golite062009
transcription regulator activity 0.010318258615897 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle