YRC Public Data Repository - Protein Structure Prediction

Protein:	GALM
Organism:	Homo sapiens
Length:	342 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GALM.

Description	E-value	Query Range	Subject Range
GALM_RAT - Aldose 1-epimerase OS=Rattus norvegicus GN=Galm PE=1 SV=1	0.0	[1..342]	[1..342]
gi\|47169179, gi\|... - gi\|47169183\|pdb\|1SO0\|D Chain D, Crystal Structure Of Human Galactose Mutarotase Complexed With Galac...	0.0	[1..342]	[3..344]
GALM_PIG - Aldose 1-epimerase OS=Sus scrofa GN=GALM PE=2 SV=1	0.0	[1..342]	[1..342]
GALM_BOVIN - Aldose 1-epimerase OS=Bos taurus GN=GALM PE=2 SV=1	0.0	[1..342]	[1..342]
gi\|73980750 - gi\|73980750\|ref\|XP_540154.2\| PREDICTED: similar to galactose mutarotase (aldose 1-epimerase) [Canis ...	0.0	[1..342]	[1..342]
GALM_MOUSE - Aldose 1-epimerase OS=Mus musculus GN=Galm PE=1 SV=1	0.0	[1..342]	[1..342]
GALM_PONPY - Aldose 1-epimerase - Pongo pygmaeus (Orangutan) GALM_PONAB - Aldose 1-epimerase OS=Pongo abelii GN=GALM PE=2 SV=1	0.0	[1..342]	[1..342]
gi\|62857539 - gi\|62857539\|ref\|NP_001017024.1\| galactose mutarotase (aldose 1-epimerase) [Xenopus tropicalis]	0.0	[1..342]	[1..342]

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Predicted Domain #1

Region A:
Residues: [1-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVTRAVFG ELPSGGGTVE KFQLQSDLLR VDIISWGCTI TALEVKDRQG RASDVVLGFA  60
   61 ELEGYLQKQP YFGAVIGRVA NRIAKGTFKV DGKEYHLAIN KEPNSLHGGV RGFDKVLWTP 120
  121 RVLSNGVQFS RISPDGEEGY PGELKVWVTY TLDGGELIVN YRAQASQATP VNLTNHSYFN 180
  181 LAGQASPNIN DHEVTIEADT YLPVDETLIP TGEVAPVQGT AFDLRKPVEL GKHLQDFHLN 240
  241 GFDHNFCLKG SKEKHFCARV HHAASGRVLE VYTTQPGVQF YTGNFLDGTL KGKNGAVYPK 300
  301 HSGFCLETQN WPDAVNQPRF PPVLLRPGEE YDHTTWFKFS VA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.0
Match:	1snzA
Description:	Crystal structure of apo human galactose mutarotase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aldose 1-epimerase activity	2.85100059704396	bayes_pls_golite062009
catalytic activity	0.770933849734279	bayes_pls_golite062009
racemase and epimerase activity, acting on carbohydrates and derivatives	0.68102716507433	bayes_pls_golite062009
racemase and epimerase activity	0.473636146090495	bayes_pls_golite062009
UDP-glucose 4-epimerase activity	0.46846097606394	bayes_pls_golite062009
binding	0.381228414514023	bayes_pls_golite062009
isomerase activity	0.106573908779409	bayes_pls_golite062009
protein binding	0.078592895113726	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: