YRC Public Data Repository - Protein Structure Prediction

Protein:	SLC17A8
Organism:	Homo sapiens
Length:	589 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLC17A8.

Description	E-value	Query Range	Subject Range
gi\|114646499 - gi\|114646499\|ref\|XP_509298.2\| PREDICTED: solute carrier family 17 (sodium-dependent inorganic phosph...	5.0E-78	[1..589]	[1..589]
gi\|109098417 - gi\|109098417\|ref\|XP_001089949.1\| PREDICTED: similar to solute carrier family 17 (sodium-dependent in...	5.0E-77	[1..589]	[1..589]
gi\|31414749 - gi\|31414749\|gb\|AAM50094.1\| vesicular glutamate transporter 3 [Rattus norvegicus]	2.0E-76	[1..589]	[1..588]
VGLU3_MOUSE - Vesicular glutamate transporter 3 OS=Mus musculus GN=Slc17a8 PE=2 SV=1	2.0E-72	[1..589]	[1..601]
gi\|76612475 - gi\|76612475\|ref\|XP_608113.2\| PREDICTED: similar to solute carrier family 17 (sodium-dependent inorga...	3.0E-72	[1..589]	[1..588]

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Predicted Domain #1

Region A:
Residues: [1-509]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFKAFDTFK EKILKPGKEG VKNAVGDSLG ILQRKIDGTT EEEDNIELNE EGRPVQTSRP  60
   61 SPPLCDCHCC GLPKRYIIAI MSGLGFCISF GIRCNLGVAI VEMVNNSTVY VDGKPEIQTA 120
  121 QFNWDPETVG LIHGSFFWGY IMTQIPGGFI SNKFAANRVF GAAIFLTSTL NMFIPSAARV 180
  181 HYGCVMCVRI LQGLVEGVTY PACHGMWSKW APPLERSRLA TTSFCGSYAG AVVAMPLAGV 240
  241 LVQYIGWSSV FYIYGMFGII WYMFWLLQAY ECPAAHPTIS NEEKTYIETS IGEGANVVSL 300
  301 SKFSTPWKRF FTSLPVYAII VANFCRSWTF YLLLISQPAY FEEVFGFAIS KVGLLSAVPH 360
  361 MVMTIVVPIG GQLADYLRSR QILTTTAVRK IMNCGGFGME ATLLLVVGFS HTKGVAISFL 420
  421 VLAVGFSGFA ISGFNVNHLD IAPRYASILM GISNGVGTLS GMVCPLIVGA MTRHKTREEW 480
  481 QNVFLIAALV HYSGVIFYGV FASGEKQEW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.69897
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
anion transmembrane transporter activity	3.94605227012838	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.0995260802482	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.0995260802482	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	2.52916479889426	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
phosphate transmembrane transporter activity	1.78662033436109	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.6904339767429	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [510-589]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADPENLSEEK CGIIDQDELA EEIELNHESF ASPKKKMSYG ATSQNCEVQK KEWKGQRGAT  60
   61 LDEEELTSYQ NEERNFSTIS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.518	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.217	a.48.3	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View	Download	0.208	a.5.6	Hypothetical protein MTH1615

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: