YRC Public Data Repository - Protein Structure Prediction

Protein:	FPG_PHOPR
Organism:	Photobacterium profundum
Length:	269 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FPG_PHOPR.

Description	E-value	Query Range	Subject Range
FPG_SHISS - Formamidopyrimidine-DNA glycosylase OS=Shigella sonnei (strain Ss046) GN=mutM PE=3 SV=3 gi\|124530495, gi... - gi\|124530495\|ref\|ZP_01701122.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli B], gi\|1244991... FPG_ECOLC - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=mu... FPG_ECO45 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mutM PE=3 SV=... FPG_SHIBS - Formamidopyrimidine-DNA glycosylase OS=Shigella boydii serotype 4 (strain Sb227) GN=mutM PE=3 SV=3 FPG_ECO81 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O81 (strain ED1a) GN=mutM PE=3 SV=1 gi\|75242586, gi\|... - gi\|75242586\|ref\|ZP_00726330.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli F11], ... FPG_ECOLU - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=mutM ... gi\|188487129, gi... - gi\|75514303\|ref\|ZP_00736611.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli 53638]... gi\|15833764, gi\|... - gi\|15833764\|ref\|NP_312537.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. Saka... FPG_SHIF8 - Formamidopyrimidine-DNA glycosylase OS=Shigella flexneri serotype 5b (strain 8401) GN=mutM PE=3 SV=1 gi\|56480390, gi\|... - gi\|56480390\|ref\|NP_709414.2\| formamidopyrimidine-DNA glycosylase [Shigella flexneri 2a str. 301], gi... gi\|208814029, gi... - gi\|208814029\|ref\|ZP_03255358.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. E... gi\|208820753, gi... - gi\|208820753\|ref\|ZP_03261073.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. E... FPG_ECO5E - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mutM PE=3 ... FPG_ECOSE - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain SE11) GN=mutM PE=3 SV=1 FPG_ECO24 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=mutM PE=... FPG_ECO27 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=mutM PE=... gi\|191167823, gi... - gi\|75229026\|ref\|ZP_00715610.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Escherichia coli B7A], ... gi\|217324519, gi... - gi\|217324519\|ref\|ZP_03440603.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. T... gi\|194430989, gi... - gi\|83571421\|ref\|ZP_00922861.1\| COG0266: Formamidopyrimidine-DNA glycosylase [Shigella dysenteriae 10... FPG_ESCF3 - Formamidopyrimidine-DNA glycosylase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0... FPG_SHIB3 - Formamidopyrimidine-DNA glycosylase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=m... FPG_ECO8A - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O8 (strain IAI1) GN=mutM PE=3 SV=1 FPG_SHIFL - Formamidopyrimidine-DNA glycosylase OS=Shigella flexneri GN=mutM PE=3 SV=3 gi\|254795590, gi... - gi\|254795590\|ref\|YP_003080427.1\| formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glyco... gi\|254038834, gi... - gi\|254038834\|ref\|ZP_04872886.1\| formamidopyrimidine-DNA glycosylase [Escherichia sp. 1_1_43], gi\|226... gi\|226902669, gi... - gi\|237703405\|ref\|ZP_04533886.1\| formamidopyrimidine-DNA glycosylase [Escherichia sp. 3_2_53FAA], gi\|... FPG_ECO57 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O157:H7 GN=mutM PE=3 SV=3 sp\|B7ULJ0\|FPG_ECO27 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=mutM PE=... gi\|168753459, gi... - gi\|189358964\|gb\|EDU77383.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC440... gi\|189369599, gi... - gi\|189369599\|gb\|EDU88015.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC450... gi\|189364460, gi... - gi\|189364460\|gb\|EDU82879.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC448... gi\|168772399, gi... - gi\|187771367\|gb\|EDU35211.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC419... gi\|189002553, gi... - gi\|189002553\|gb\|EDU71539.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC407... gi\|189374639, gi... - gi\|189374639\|gb\|EDU93055.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC869... FPG_ECOSM - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=mutM PE=3 SV=1 gi\|195936196 - gi\|195936196\|ref\|ZP_03081578.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. E... FPG_ECOUT - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli (strain UTI89 / UPEC) GN=mutM PE=3 SV=1 gi\|30065089, gi\|... - gi\|30065089\|ref\|NP_839260.1\| formamidopyrimidine-DNA glycosylase [Shigella flexneri 2a str. 2457T], ... gi\|209754676, gi... - pir\|\|G86039 formamidopyrimidine DNA glycosylase [imported] - Escherichia coli (strain O157:H7, subst... gi\|15804176, gi\|... - gi\|15804176\|ref\|NP_290215.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 EDL933], ... FPG_ECOK1 - Formamidopyrimidine-DNA glycosylase OS=Escherichia coli O1:K1 / APEC GN=mutM PE=3 SV=1 gi\|188016969, gi... - gi\|188016969\|gb\|EDU55091.1\| formamidopyrimidine-DNA glycosylase [Escherichia coli O157:H7 str. EC411...	387.0	[0..1]	[269..1]

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Predicted Domain #1

Region A:
Residues: [1-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPELPEVEVS RMGITPHMVG QTVTKIIVRN PKLRWPIPEE IQQIEGQVIR KVTRRAKYLL  60
   61 LHTDVGYAIV HLGMSGSLRI LPASIPPEKH DHVDLVLSSG EVLRYNDPRR FGAWLWGLPD 120
  121 LDHKVLSQLG PEPLSNDFTA EYLQERAKGK RTAIKQFIMD NKVVVGVGNI YANESLFSAG 180
  181 IHPKRAAGEI SPEKIALFVD EIKSVLAFAI EQGGTTLKDF KNADGKPGYF AQELQVYGKG 240
  241 GKPCPRCDNP LSEMKIGQRA SVFCSECQK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	106.0
Match:	1k82A
Description:	DNA repair protein MutM (Fpg)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.06377793944255	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	3.68895100180378	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	3.63831813037192	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	3.50273405950314	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.32722481172627	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.59048389792519	bayes_pls_golite062009
hydrolase activity	1.74627738237592	bayes_pls_golite062009
binding	1.7313696856499	bayes_pls_golite062009
DNA binding	1.22619720972604	bayes_pls_golite062009
nucleic acid binding	1.17199530230795	bayes_pls_golite062009
transcription regulator activity	1.16376707327858	bayes_pls_golite062009
protein binding	1.14219782236887	bayes_pls_golite062009
transcription factor activity	0.472763834470731	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009
lyase activity	0.0836281676510939	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: