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View Structure Prediction Details

Protein: PANK4
Organism: Homo sapiens
Length: 773 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PANK4.

Description E-value Query
Range		 Subject
Range
gi|108995777 - gi|108995777|ref|XP_001086116.1| PREDICTED: pantothenate kinase 4 isoform 2 [Macaca mulatta]
 0.0 [1..773] [1..773]
PANK4_MACFA - Pantothenate kinase 4 OS=Macaca fascicularis GN=PANK4 PE=2 SV=2
 0.0 [1..773] [1..773]
PANK4_PONPY - Pantothenate kinase 4 - Pongo pygmaeus (Orangutan)
PANK4_PONAB - Pantothenate kinase 4 OS=Pongo abelii GN=PANK4 PE=2 SV=1
 0.0 [1..773] [1..773]
gi|62898824 - gi|62898824|dbj|BAD97266.1| pantothenate kinase 4 variant [Homo sapiens]
 0.0 [1..773] [1..773]
PANK4_RAT - Pantothenate kinase 4 OS=Rattus norvegicus GN=Pank4 PE=1 SV=1
 0.0 [1..773] [1..773]
gi|27370494, gi|... - gi|27370494|ref|NP_766578.1| pantothenate kinase 4 [Mus musculus], gi|26341576|dbj|BAC34450.1| unnam...
 0.0 [1..771] [1..771]
gi|73956621 - gi|73956621|ref|XP_536718.2| PREDICTED: similar to pantothenate kinase 4 [Canis familiaris]
 0.0 [1..773] [1..773]

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Predicted Domain #1
Region A:
Residues: [1-404] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY YSTVQHKVAK  60
   61 VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY IEACLDFIKD HLVNTETKVI 120
  121 QATGGGAYKF KDLIEEKLRL KVDKEDVMTC LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ 180
  181 TNHPHIFPYL LVNIGSGVSI VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH 240
  241 LASRGQHSNV DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS 300
  301 NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA LFLRHEGYLG 360
  361 AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ RARS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 145.0
Match: 2i7nA
Description: No description for 2i7nA was found.

Predicted functions:

Term Confidence Notes
structural constituent of cytoskeleton 2.46121037473545 bayes_pls_golite062009
cytoskeletal protein binding 2.20983242331685 bayes_pls_golite062009
binding 1.97067859459221 bayes_pls_golite062009
pantothenate kinase activity 1.44039088435404 bayes_pls_golite062009
carbohydrate kinase activity 1.3713660758447 bayes_pls_golite062009
protein binding 1.16405332128302 bayes_pls_golite062009
actin binding 1.03829083423378 bayes_pls_golite062009
structural molecule activity 0.963253603902027 bayes_pls_golite062009
hydrolase activity 0.921698825968978 bayes_pls_golite062009
kinase activity 0.90616568759573 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.797242642077629 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.59082563232385 bayes_pls_golite062009
hexokinase activity 0.49038289556657 bayes_pls_golite062009
myosin binding 0.31501932970343 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
transferase activity 0.105619024604158 bayes_pls_golite062009
nucleic acid binding 0.101675282305395 bayes_pls_golite062009
unfolded protein binding 0.0304569608189402 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [405-773] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTFDLLEMDR LERPLVDLPL LLDPPSYVPD TVDLTDDALA RKYWLTCFEE ALDGVVKRAV  60
   61 ASQPDSVDAA ERAEKFRQKY WNKLQTLRQQ PFAYGTLTVR SLLDTREHCL NEFNFPDPYS 120
  121 KVKQRENGVA LRCFPGVVRS LDALGWEERQ LALVKGLLAG NVFDWGAKAV SAVLESDPYF 180
  181 GFEEAKRKLQ ERPWLVDSYS EWLQRLKGPP HKCALIFADN SGIDIILGVF PFVRELLLRG 240
  241 TEVILACNSG PALNDVTHSE SLIVAERIAG MDPVVHSALQ EERLLLVQTG SSSPCLDLSR 300
  301 LDKGLAALVR ERGADLVVIE GMGRAVHTNY HAALRCESLK LAVIKNAWLA ERLGGRLFSV 360
  361 IFKYEVPAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.0
Match: 1xfiA
Description: X-ray structure of gene product from Arabidopsis thaliana At2g17340
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle