YRC Public Data Repository - Protein Structure Prediction

Protein:	PPIL3
Organism:	Homo sapiens
Length:	161 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPIL3.

Description	E-value	Query Range	Subject Range
gi\|114582751 - gi\|114582751\|ref\|XP_516021.2\| PREDICTED: similar to cyclophilin-like protein PPIL3b [Pan troglodytes...	2.0E-58	[2..161]	[159..318]
gi\|50301248 - gi\|50301248\|gb\|AAT73777.1\| TRIM5/cyclophilin A fusion protein [Aotus trivirgatus]	2.0E-58	[2..155]	[319..474]
gi\|73981864 - gi\|73981864\|ref\|XP_540355.2\| PREDICTED: similar to peptidylprolyl isomerase-like protein 3 isoform P...	6.0E-56	[1..161]	[55..215]
CPY71_ARATH - Peptidyl-prolyl cis-trans isomerase CYP71 OS=Arabidopsis thaliana GN=CYP71 PE=1 SV=1	1.0E-55	[2..154]	[477..628]
gi\|49523292, gi\|... - gi\|89268872\|emb\|CAJ81475.1\| peptidylprolyl isomerase (cyclophilin)-like 3 [Xenopus tropicalis], gi\|5...	2.0E-55	[1..160]	[1..160]
gi\|50948445, gi\|... - gi\|50948445\|ref\|XP_483750.1\| putative cyclophilin (70.8 kD) (cyp-15) [Oryza sativa (japonica cultiva...	3.0E-55	[2..154]	[269..420]
gi\|55730219, gi\|... - gi\|75061782\|sp\|Q5R8S7\|PPIA_PONPY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (Rotamase A) (Cycl... gi\|197098846 - gi\|197098846\|ref\|NP_001126060.1\| peptidylprolyl isomerase A [Pongo abelii]	3.0E-55	[1..156]	[8..165]
gi\|50344948, gi\|... - gi\|50344948\|ref\|NP_001002146.1\| peptidylprolyl isomerase-like 3 [Danio rerio], gi\|47937917\|gb\|AAH713...	7.0E-55	[1..160]	[1..160]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVTLHTDVG DIKIEVFCER TPKTCENFLA LCASNYYNGC IFHRNIKGFM VQTGDPTGTG  60
   61 RGGNSIWGKK FEDEYSEYLK HNVRGVVSMA NNGPNTNGSQ FFITYGKQPH LDMKYTVFGK 120
  121 VIDGLETLDE LEKLPVNEKT YRPLNDVHIK DITIHANPFA Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.0
Match:	1xyhA
Description:	Crystal Structure of Recombinant Human Cyclophilin J
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidyl-prolyl cis-trans isomerase activity	3.73853378771688	bayes_pls_golite062009
cis-trans isomerase activity	3.66963215732405	bayes_pls_golite062009
isomerase activity	1.96529188741504	bayes_pls_golite062009
binding	1.46018233647024	bayes_pls_golite062009
unfolded protein binding	1.38124355054041	bayes_pls_golite062009
RNA binding	1.36609500767021	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
mRNA binding	0.210589563207907	bayes_pls_golite062009
protein binding	0.130251391659493	bayes_pls_golite062009
hydrolase activity	0.126773806019757	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: