YRC Public Data Repository - Protein Structure Prediction

Protein:	MSH2
Organism:	Homo sapiens
Length:	934 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSH2.

Description	E-value	Query Range	Subject Range
MSH2_CHLAE - DNA mismatch repair protein Msh2 OS=Chlorocebus aethiops GN=MSH2 PE=2 SV=1	0.0	[1..934]	[1..933]
MSH2_BOVIN - DNA mismatch repair protein Msh2 OS=Bos taurus GN=MSH2 PE=2 SV=1	0.0	[1..931]	[1..931]
MSH2_MOUSE - DNA mismatch repair protein Msh2 OS=Mus musculus GN=Msh2 PE=1 SV=1	0.0	[1..931]	[1..931]
gi\|73969550 - gi\|73969550\|ref\|XP_538482.2\| PREDICTED: similar to DNA mismatch repair protein Msh2 (MutS protein ho...	0.0	[1..934]	[1..934]
MSH2_RAT - DNA mismatch repair protein Msh2 OS=Rattus norvegicus GN=Msh2 PE=2 SV=1	0.0	[1..931]	[1..931]
gi\|55733310 - gi\|55733310\|emb\|CAH93337.1\| hypothetical protein [Pongo abelii] gi\|55733310\|emb\|... - hypothetical protein [Pongo pygmaeus]	0.0	[1..878]	[1..878]
gi\|1079805 - gi\|1079805\|gb\|AAA82080.1\| similar to S. cerevisiae Msh2p (Swiss-Prot accession number P25847) and ba...	0.0	[1..880]	[1..880]

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Predicted Domain #1

Region A:
Residues: [1-934]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA LLAAREVFKT  60
   61 QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV EVYKNRAGNK ASKENDWYLA 120
  121 YKASPGNLSQ FEDILFGNND MSASIGVVGV KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD 180
  181 NDQFSNLEAL LIQIGPKECV LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD 240
  241 LNRLLKGKKG EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM 300
  301 KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL MDKNRIEERL 360
  361 NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN LQDCYRLYQG INQLPNVIQA 420
  421 LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF QEMIETTLDM DQVENHEFLV KPSFDPNLSE 480
  481 LREIMNDLEK KMQSTLISAA RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS 540
  541 TVDIQKNGVK FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA 600
  601 QLDAVVSFAH VSNGAPVPYV RPAILEKGQG RIILKASRHA CVEVQDEIAF IPNDVYFEKD 660
  661 KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA EVSIVDCILA RVGAGDSQLK 720
  721 GVSTFMAEML ETASILRSAT KDSLIIIDEL GRGTSTYDGF GLAWAISEYI ATKIGAFCMF 780
  781 ATHFHELTAL ANQIPTVNNL HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPKHV 840
  841 IECAKQKALE LEEFQYIGES QGYDIMEPAA KKCYLEREQG EKIIQEFLSK VKQMPFTEMS 900
  901 EENITIKLKQ LKAEVIAKNN SFVNEIISRI KVTT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	2o8bA
Description:	No description for 2o8bA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits