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View Structure Prediction Details

Protein: gi|3511153, gi|2...
Organism: Homo sapiens
Length: 327 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|3511153, gi|2....

Description E-value Query
Range		 Subject
Range
FTSJ1 - FtsJ homolog 1 (E. coli)
 8.0E-93 [1..327] [1..329]
gi|74006842 - gi|74006842|ref|XP_862799.1| PREDICTED: similar to FtsJ homolog 1 isoform b isoform 2 [Canis familia...
 7.0E-92 [1..327] [1..327]
gi|123229060, gi... - gi|22028410|gb|AAH34880.1| FtsJ homolog 1 (E. coli) [Mus musculus], gi|123229060|emb|CAM17937.1| Fts...
 2.0E-91 [1..325] [1..322]
gi|109130592 - gi|109130592|ref|XP_001097658.1| PREDICTED: FtsJ homolog 1 [Macaca mulatta]
 4.0E-90 [1..327] [1..329]
gi|109511566, gi... - gi|109511566|ref|XP_001062916.1| PREDICTED: similar to Ftsj homolog isoform 1 [Rattus norvegicus], g...
 1.0E-85 [1..326] [1..325]
gi|55726462 - gi|55726462|emb|CAH90000.1| hypothetical protein [Pongo abelii]
gi|55726462|emb|... - hypothetical protein [Pongo pygmaeus]
 1.0E-84 [1..317] [1..319]
gi|76634246 - gi|76634246|ref|XP_595849.2| PREDICTED: similar to Putative ribosomal RNA methyltransferase 1 (rRNA ...
 3.0E-70 [44..326] [3..287]

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Predicted Domain #1
Region A:
Residues: [1-215] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRTSKDKRD VYYRLAKENG WRARSAFKLL QLDKEFQLFQ GVTRAVDLCA APGSWSQVLS  60
   61 QKIGGQGSGH VVAVDLQAMA PLPGVVQIQG DITQLSTAKE IIQHFKGCPA DLVVCDGAPD 120
  121 VTGLHDVDEY MQAQLLLAAL NIATHVLKPG GCFVAKIFRG RDVTLLYSQL QVFFSSVLCA 180
  181 KPRSSRNSSI EAFAVCQGYD PPEGFIPDLS KPLLD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.045757
Match: 1eizA
Description: RNA methyltransferase FtsJ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
rRNA methyltransferase activity 4.09362182773099 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 1.83964463328968 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 1.75675289134467 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 1.10713374933008 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.71058003448013 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.698509190696763 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.364369105571521 bayes_pls_golite062009
O-methyltransferase activity 0.250946859465502 bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity 0.234572322347698 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [216-327] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSYDFNQLDG PTRIIVPFVT CGDLSSYDSD RSYPLDLEGG SEYKYTPPTQ PPISPPYQEA  60
   61 CTLKRKGQLA KEIRPQDCPI SRVDTFPQPL AAPQCHTLLA PEMEDNEMSC SP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle